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ProteomicsUnveiling the unfolded proteome: evaluation and comparison of methods for the enrichment of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) comprise a significant fraction of the eukaryotic proteome and are characterised by the absence of stable secondary or tertiary structures under physiological conditions. Despite their functional importance, comprehensive proteomic analysis of IDPs remains a ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070700 | Pride
Heat extraction Lc-ms Intrinsically disordered proteins Prefractionation methods Label-free quantification Perchloric acid extraction Disorder prediction algorithm Instrinsically disordered proteins enrichment 
ProteomicsProteomic and bioinformatic analysis of the nuclear intrinsically disordered proteome
Intrinsically disordered proteins (IDPs) are biologically active molecules which are involved in many cellular functions although they do not possess a defined three-dimensional structure. They are mostly signalling and regulatory proteins. This study is the first large-scale proteomic analysis of t...
ORGANISM(S): Homo sapiens (Human) 
2015-09-21 | PXD002676 | Pride
Nuclear proteome Subproteome Transcription factors Intrinsically disordered proteins 
UnknownThe alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins.
Not available
S-EPMC5424795 | biostudies-literature
ProteomicsProteomic analysis of cancer-related alterations in the human unfoldome
In this study, we explore the role of intrinsically disordered proteins (IDPs) in human breast cancer within the context of the "unfoldome." Using advanced proteomic techniques, we identified 2,271 protein groups in both normal and cancerous cell proteomes. Notably, 148 IDPs displayed significant di...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD047284 | Pride
Unfoldome Idps Cancer 
ProteomicsThe C-terminus of the PSMA3 proteasome subunit preferentially traps intrinsically disordered proteins for degradation
Degradation of intrinsically disordered proteins (IDPs) by a non-26S proteasome process does not require proteasomal targeting by polyubiquitin. However, whether and how IDPs are recognized by the non-26S proteasome, including the 20S complex, remains unknown. Analyses of protein interactome dataset...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024791 | Pride
Proteasome Disordered proteins Proteomics 
UnknownTargeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept.
Not available
S-EPMC3371274 | biostudies-literature
UnknownArchaic chaos: intrinsically disordered proteins in Archaea.
Not available
S-EPMC2880407 | biostudies-literature
UnknownIntrinsically disordered proteins (IDPs) in trypanosomatids.
Not available
S-EPMC4378006 | biostudies-literature
UnknownUnreported intrinsic disorder in proteins: Building connections to the literature on IDPs.
Not available
S-EPMC5314882 | biostudies-literature
UnknownAn optimized Npro-based method for the expression and purification of intrinsically disordered proteins for an NMR study.
Not available
S-EPMC5314886 | biostudies-literature
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