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TranscriptomicsRNAseq and Lariat sequencing of different S. pombe growth conditions
We performed lariat sequencing to profile the diversity of spliced RNA lariats in S. pombe identify annotated and alternate introns. Three different growth conditions were used to grow S. pombe wt and S. pombe Δdbr1. Lariat sequencing of the Δdbr1 strains and RNAseq of the wt and Δdbr1 strains were ...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-03 | E-GEOD-68345 | biostudies-arrayexpress
TranscriptomicsCwc23, an essential J-protein critical for pre-mRNA splicing with a dispensable J-domain
J-proteins are structurally diverse, obligatory co-chaperones of Hsp70s, each with a highly conserved J-domain that plays a critical role in stimulation of Hsp70’s ATPase activity. The essential protein, Cwc23, is one of 13 J-proteins found in the cytosol and/or nucleus of Saccharomyces cerevisiae...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-21 | E-GEOD-18485 | biostudies-arrayexpress
UnknownBreaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.
Not available
S-EPMC3079748 | biostudies-literature
ProteomicsThe Debranching Enzyme Dbr1 Regulates Lariat Turnover and Intron Splicing
The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting step of lariat turnover. Through generation of the first v...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-26 | MSV000092263 | MassIVE
UnknownAll-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome.
Not available
S-EPMC6042132 | biostudies-literature
ProteomicsSpliceosome disassembly factors ILP1 and NTR1 promote microRNA biogenesis in Arabidopsis
A battery of spliceosome-associated proteins has been identified in microRNA (miRNA) biogenesis; however, the underlying mechanisms remain elusive. The intron lariat spliceosome (ILS) complex is highly conserved among eukaryotes and its disassembly marks the end of a canonical splicing cycle. In thi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-11-12 | PXD011542 | Pride
Alternative splicing Transcription Mirna Circadian clock Intron lariat spliceosome 
UnknownIntron lariat spliceosomes convert lariats to true circles: implications for intron transposition.
Not available
S-EPMC11146597 | biostudies-literature
UnknownIntron-lariat spliceosomes convert lariats to true circles: implications for intron transposition.
Not available
S-EPMC10996645 | biostudies-literature
ProteomicsMechanism of spliceosome termination
After removing an intron from pre-mRNA, the spliceosome becomes trapped in a non productive complex bound to the excised intron. The termination of this complex is critical for spliceosome recycling and intron decay, but the underlying mechanism remains unknown. Here, we present cryo-electron micros...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD078004 | Pride
Spliceosome 
UnknownCrystal structure of a eukaryotic group II intron lariat.
Not available
S-EPMC4197185 | biostudies-literature
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