Ion-channel - OmicsDI

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Organisms

Mus musculus (139)
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Technology Type

Mass Spectrometry (877)
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Instrument Platform

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Illumina HiSeq 2500 (8)
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NextSeq 2000 (3)
Single nuclei were captured using the 10x Genomics Chromium Controller. (2)
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Publication Date

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2004 (4)

CHEBI ID

CHEBI:18237 (8)
CHEBI:28044 (8)
CHEBI:16919 (8)
CHEBI:17596 (8)
CHEBI:17368 (8)
CHEBI:26271 (7)
CHEBI:25094 (7)
CHEBI:27570 (7)
CHEBI:18186 (7)
CHEBI:28300 (7)
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CHEBI:16566 (6)
CHEBI:27266 (6)
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CHEBI:29016 (6)
CHEBI:16015 (6)
CHEBI:32816 (6)
CHEBI:27897 (6)
CHEBI:30769 (6)
CHEBI:16113 (5)

Metabolite Name

Cholic acid (13)
Inosine (13)
9,12,13-TriHOME (12)
DCMP (12)
L-Histidine (12)
L-Tryptophan (12)
Xanthine (12)
Thymidine (12)
Glutathione (11)
Adrenic acid (11)
Hexadecanedioic acid (11)
Guanosine (11)
Uridine (11)
Deoxyuridine (10)
3alpha-Hydroxy-3,5-dihydromonacolin L acid (10)
Sulfate (10)
Indolelactic acid (10)
Tetradecanedioic acid (10)
N-Acetyl-L-phenylalanine (10)
Dodecanedioic acid (10)
Azelaic acid (10)
Uric acid (10)
Tobramycin (9)
6-Hydroxymelatonin (9)
L-Histidinol (9)
Gentamicin C1 (9)
9,10-DHOME (9)
Emindole SB (9)
20-Oxo-5-O-beta-mycaminosyltylactone (9)
UMP (9)

First Public Date

2026 (94)
2025 (52)
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2015 (8)
2013 (8)
2016 (2)
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Modelling Approach

Ordinary differential equation model (5)
Deep learning (1)
Differential algebraic equation model (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (60)
Harvard Medical School (12)
Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK (10)
Cambridge Institute for Medical Research, University of Cambridge (7)
Department of Cell Biology, Harvard Medical School, Boston MA 02115 USA (7)
David H. Koch Institute for Integrative Cancer Research Howard Hughes Medical Institute Massachusetts Institute of Technology Cambridge, MA 02139, USA (6)
Department of Cell Biology, Harvard Medical School, Boston MA, USA (6)
Department of Cell Biology, Harvard Medical School, Boston, MA, USA (6)
Department of Cell Biology Harvard Medical School Boston, MA 02115 (5)
Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA (5)
The Institute of Cancer Research (5)
CRUK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way CB2 0RE Cambridge United Kingdom (4)
CRUK Scotland Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (4)
Department of Clinical Science, University of Bergen, Norway (4)
Director of Women’s Health Research Women’s Service Line Inova Health System (4)
Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany Frankfurt Cancer Institute, Frankfurt am Main, Germany Cardio-Pulmonary Institute, Frankfurt am Main, Germany (4)
Laboratory of Microbiology Oceanography, State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, School of Oceanography, Shanghai JiaoTong University (4)
1School of Natural Sciences, Macquarie University, Sydney, NSW, Australia 2Institute for Glyco-core Research (iGCORE), Nagoya University, Aichi, Japan (3)
Cell Biology Department, Harvard Medical School (3)
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA. (3)
Department of Biology, Institute of Microbiology, ETH Zürich, Switzerland (3)
Department of Cell Biology Harvard Medical School Boston, MA, USA (3)
Department of Cell Biology, Harvard Medical School, USA (3)
Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway (3)
Department of Laboratory Medicine and Pathology, Mayo Clinic (3)
Dr. Alexander Schmidt Proteomics Core Facility Biozentrum, University of Basel Klingelbergstrasse 50/70 CH-4056 Basel / Switzerland (3)
ETH Zurich (3)
Institute of Biochemistry (IBC, ETHZ) (3)
Massachusetts Institute of Technology (3)
Molecular Oncology Chemical Biology and Molecular Medicine Moffitt Cancer Center (3)

IsPrivate

False (7)

Submitter Keywords

Ersilia (1)
FAIR-AIML (1)
Machine Learning Model (1)
TransQST (1)

Classification

bacteria (2)
fungi (1)

Modification

-17.026549 (2)
15.994915 (2)
42.010565 (2)
57.021464 (2)
-18.010565 (1)
31.989829 (1)
79.966331 (1)
N6 (1)
Not available (1)

Study type

Transcription profiling by array (559)
RNA-seq of coding RNA (84)
ChIP-seq (39)
RNA-seq of coding RNA from single cells (15)
Methylation profiling by array (14)
Unknown experiment type (13)
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Animal - High-throughput sequencing (6)
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RNA-seq of total RNA (3)
Differential (2)
Human - High-throughput sequencing (2)
Spatial transcriptomics by high-throughput sequencing (2)
Single-nucleus ATAC-seq (1)
Animal - One-color microarray (1)
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Capture-C (1)

Release Date

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2004 (53)
2003 (39)
2001 (23)
2002 (17)
1997 (10)
2000 (9)
1998 (9)
1999 (6)

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The ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch

Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...

ORGANISM(S): Danio rerio

2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies

Targeted protein degradation or downregulation (TPD/TPDR) mediated by induced recruitment of an endogenous E3 ubiquitin ligase to a substrate is a disruptive paradigm for developing therapeutics. However, <2% of ~600 E3 ligases have been exploited for this modality, and efficacy for multi-subunit me...

ORGANISM(S): Homo sapiens (Human)

2026-01-19 | PXD069051 | Pride

Temporal neocortex mesial temporal lobe epilepsy

Ion channel splice array data collected from temporal neocortex brain tissue collected from patients with mesial temporal lobe epilepsy. Temporal cortex samples from control subjects were compared to temporal neocortex of patients with mesial temporal lobe epilepsy

ORGANISM(S): Homo sapiens

2010-06-11 | E-GEOD-6773 | biostudies-arrayexpress

Molecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy

Ischemic cardiomyopathy (ICM) leads to congestive heart failure and can cause sudden cardiac death due to arrhythmia. Existing molecular knowledge base of ICM is rudimentary because of lack of specific attribution to cell type and function. This study was designed to investigate cell-specific molecu...

ORGANISM(S): Homo sapiens

2010-05-14 | E-GEOD-17294 | biostudies-arrayexpress

Cerebellum Alzheimer's Disease

Ion channel splice array data from cerebellum brain tissue samples collected from Alzheimer's disease patients. Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects were compared to ...

ORGANISM(S): Homo sapiens

2010-06-11 | E-GEOD-6777 | biostudies-arrayexpress

Temporal Cortex Alzheimer's Disease

Ion channel splice array data from temporal cortex brain tissue samples collected from Alzheimer's disease patients. Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects were compare...

ORGANISM(S): Homo sapiens

2010-06-11 | E-GEOD-6775 | biostudies-arrayexpress

Cerebellum Control (Alzheimer's disease control)

Ion channel splice array data from cerebellum brain tissue samples collected from control (non Alzheimer's disease) subjects. Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects wer...

ORGANISM(S): Homo sapiens

2010-06-11 | E-GEOD-6778 | biostudies-arrayexpress

Temporal Cortex Control (Alzheimer's disease control)

Ion channel splice array data from temporal cortex brain tissue samples collected from control subjects (no Alzheimer's disease). Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects...

ORGANISM(S): Homo sapiens

2010-06-11 | E-GEOD-6774 | biostudies-arrayexpress

Mechanosensitive ion channel regulates tissue stiffening to promote glioma aggression

PRJNA450606 | ENA

Modulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker- like cells

Background: Ion channels are key determinants for the function of excitable cells but little is known about their role and involvement during cardiac development. Earlier work identified Ca2+-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural...

ORGANISM(S): Mus musculus

2011-01-03 | E-GEOD-18660 | biostudies-arrayexpress

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