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MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
TranscriptomicsRNA-seq of PBT2-Zn treated Fusobacterium nucleatum cells in vitro
To investigate the effect of the Zn ionophore, PBT2, on the transcriptomic response of Fusobacterium nucleatum ATCC 25586, RNA was extracted from bacterial samples which had been treated as follows: Untreated (0.006% DMSO v/v), DMSO-Zn treated (0.006% DMSO v/v + 200 uM ZnSO4), or PBT2-Zn treated (0....
ORGANISM(S): Fusobacterium nucleatum 
2021-07-15 | E-MTAB-8681 | biostudies-arrayexpress
UnknownChemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.
Not available
S-EPMC6299484 | biostudies-literature
ProteomicsStaphylococcus aureus mutants resistant to the feed-additive monensin show increased virulence and altered purine metabolism
Ionophores are antibacterial compounds that affect bacterial growth by changing intracellular concentrations of the essential cations, sodium and potassium. They are extensively used in animal husbandry to increase productivity and reduce infectious diseases. Given their widespread usage, it is impo...
ORGANISM(S): Staphylococcus aureus 
2024-01-09 | PXD047199 | Pride
Virulence Monensin Purine metabolism S. aureus Ionophore resistance 
UnknownFluorous polymeric membranes for ionophore-based ion-selective potentiometry: how inert is Teflon AF?
Not available
S-EPMC3227678 | biostudies-literature
ProteomicsAKT1 confers tumor resistance to cuproptosis by phosphorylating FDX1
Cuproptosis, a recently defined copper-dependent cell death, remains largely unexplored in tumor therapies, particularly in breast cancer. Our study demonstrates that triple-negative breast cancer (TNBC) bears a relative elevated copper levels and exhibit resistance to cuproptosis. Mechanistically, ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058176 | Pride
Cuproptosis 
UnknownInhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore.
Not available
S-EPMC4068593 | biostudies-literature
UnknownThe microbiome-derived antibacterial lugdunin acts as a cation ionophore in synergy with host peptides.
Not available
S-EPMC11389392 | biostudies-literature
TranscriptomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model
This study reports on the co-administration of a zinc ionophore (PBT-2) and ampicillin to break antibiotic resistance of Streptococcus pneumoniae in a murine pneumonia model. The molecular mechanism for this heightened antimicrobial activity was identified through transcriptomic and metabolomic anal...
ORGANISM(S): Streptococcus pneumoniae 
2022-02-01 | GSE159901 | GEO
UnknownPolyether ionophore resistance in a one health perspective
Not available
S-EPMC10863045 | biostudies-literature
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