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ProteomicsVascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and IP3R-evoked Ca2+/CaMK2 signal pathway
Vascular endothelial growth factor B (VEGFB) plays a crucial role in glucolipid metabolism and is highly associated with type 2 diabetes mellitus (T2DM). The role of VEGFB in the insulin secretion of β cells remains unverified. Thus, this study aims to discuss the effect of VEGFB on regulating insul...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD043843 | Pride
Β cell Insulin secretion Vegfb Plcγ/ip3r Ca2+/camk2 T2dm 
GenomicsTranscriptomic screen to identify genes regulated by IP3R in Drosophila third-instar larval nervous system
Transcriptomic screen to identify genes regulated by IP3R in Drosophila third-instar larval nervous system
PRJNA431574 | ENA
Metabolomics1H NMR Metabolomics Reveals Association of High Expression of Inositol 1, 4, 5 Trisphosphate Receptor and Metabolites in Breast Cancer Patients
1H NMR is used to detect alterations in metabolites and their linkage to metabolic processes in a number of pathological conditions including breast cancer. Inositol 1, 4, 5 trisphosphate (IP3R) receptor is an intracellular calcium channel known to regulate metabolism and cellular bioenergetics. Its...
2017-07-18 | MTBLS326 | MetaboLights
UnknownIP3R Channels in Male Reproduction.
Not available
S-EPMC7730405 | biostudies-literature
TranscriptomicsTranscriptomic screen to identify genes regulated by IP3R in Drosophila third-instar larval nervous system
Organisms need to co-ordinate growth with development particularly in the context of nutrient availability. Thus, multiple ways have evolved to survive extrinsic nutrient deprivation during development. In the holometabolous insect Drosophila, growth occurs during larval development.  Larvae are the...
ORGANISM(S): Drosophila melanogaster 
2019-03-01 | GSE109637 | GEO
UnknownSTIM-IP3R crosstalk regulates migration of breast cancer cells.
Not available
S-EPMC12302952 | biostudies-literature
UnknownIP3R-dependent mitochondrial dysfunction mediates C5b-9-induced ferroptosis in trichloroethylene-caused immune kidney injury.
Not available
S-EPMC10294229 | biostudies-literature
UnknownParkin Deficiency Impairs ER-Mitochondria Associations and calcium homeostasis via IP3R-Grp75-VDAC1 Complex.
Not available
S-EPMC12781089 | biostudies-literature
UnknownAssociation of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry.
Not available
S-EPMC6125598 | biostudies-literature
UnknownANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle.
Not available
S-EPMC10499037 | biostudies-literature
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