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ProteomicsVascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and IP3R-evoked Ca2+/CaMK2 signal pathway
Vascular endothelial growth factor B (VEGFB) plays a crucial role in glucolipid metabolism and is highly associated with type 2 diabetes mellitus (T2DM). The role of VEGFB in the insulin secretion of β cells remains unverified. Thus, this study aims to discuss the effect of VEGFB on regulating insul...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD043843 | Pride
Β cell Insulin secretion Vegfb Plcγ/ip3r Ca2+/camk2 T2dm 
UnknownCAMK2-Dependent Signaling in Neurons Is Essential for Survival.
Not available
S-EPMC6616294 | biostudies-literature
UnknownThe dysregulated expression and functional effect of CaMK2 in cancer.
Not available
S-EPMC8243487 | biostudies-literature
UnknownActivation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer.
Not available
S-EPMC11845518 | biostudies-literature
UnknownVascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2+/CaMK2 signaling pathway.
Not available
S-EPMC10510031 | biostudies-literature
GenomicsIdentification of CaMKII-dependent H3S28p target genes
To identify direct CaMKII-dependent downstream genes of H3S28p we used chromatin-immunoprecipitation followed by massive parallel DNA sequencing (ChIPseq) analysis of isolated adult murine cardiomyocytes from CamKII WT as well as from CaMKIIγ/CaMKIIδ double knockout (DKO) . DKO and WT cells were sub...
ORGANISM(S): Mus musculus 
2019-06-13 | E-MTAB-8011 | biostudies-arrayexpress
TranscriptomicsCaMKII inhibition in smooth muscle cells controls Ang-II-induced gene transcription in the aorta
The Ca2+/calmodulin-dependent kinase II is expressed in smooth muscle and believed to mediate intracellular calcium handling and calcium-dependent gene transcription. CaMKII is activated by Angiotensin-II. The multifunctional calcium/calmodulin-dependent kinase II (CaMKII) is activated by Angiotensi...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-64613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hippocampi from wild type and alpha-CaMKII+/- mice
Comparison of the hippocampus of alpha-CaMKII+/- mice with control
ORGANISM(S): Mus musculus 
2008-10-04 | E-MEXP-962 | biostudies-arrayexpress
TranscriptomicsCRAC channel controls the differentiation of pathogenic B cells in lupus nephritis
Systemic lupus erythematous (SLE) is a prototype of autoimmune disease. Lupus nephritis (LN) is one of the most serious complications of SLE. The development of autoreactive B cells and the production of autoantibodies have been critical for the initiation and progression of LN. Store-operated Ca2+ ...
ORGANISM(S): Homo sapiens 
2021-09-01 | GSE175424 | GEO
GenomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction [ChIP-seq]
The interior of the neuronal cell nucleus is a highly organized 3-dimensional (3D) structure in which regions of the genome that are millions of bases apart participate in specialized sub-structures with dedicated functions. To investigate neuronal chromatin organization and dynamics in vivo, we gen...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56809 | biostudies-arrayexpress
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