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TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
TranscriptomicsGenomic Phenotype Of Non-Cultured IPF Fibroblasts
The activated fibroblast is the central effector cell for the progressive fibrotic process that characterizes idiopathic pulmonary fibrosis (IPF). An understanding of the genomic phenotype of this cell in isolation is essential to the understanding of disease pathogenesis and is integral to strategi...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-17978 | biostudies-arrayexpress
TranscriptomicsForkhead Box F1 (FOXF1) represses fibroblast functions relevant to fibrogenesis
Aberrant expression of master phenotype regulators by lung fibroblasts may play a central role in idiopathic pulmonary fibrosis (IPF). Interrogating IPF fibroblast transcriptome datasets, we identified Forkhead Box F1 (FOXF1), a DNA-binding protein required for lung development, as a candidate actor...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-52612 | biostudies-arrayexpress
ProteomicsTargeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease in the world, but has limited clinical therapies. Fibrosis maintains dynamic balance with overactivated fibroblasts. Given pulmonary cell regeneration, the lung may have self-repairing ability if fibrosis is removed by clearance of overact...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-19 | PXD053333 | Pride
Ipf Mouse Lnp Car-t Lung 
ProteomicsMitochondrial proteomics reveals reductive metabolism dependent on glutamine in fibroblasts of idiopathic pulmonary fibrosis under hypoxia
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), is a chronic disease characterized not only by a transcriptionally active signature associated with hypoxia but also by feedback loops that may underlie disease progression. IPF fibroblasts are known to contribute to disease by th...
ORGANISM(S): Homo sapiens (Human) 
2025-11-05 | PXD064472 | Pride
Lung fibroblasts Mitochondria Proteome Ipf 
GenomicsRNA seq of IPF fibroblasts
iPSC secretome alters metabolic pathway in IPF fibroblasts
PRJEB32996 | ENA
GenomicsDifferences between fibroblasts derived from normal and IPF lungs
Differences between fibroblasts derived from normal and IPF lungs
PRJNA768413 | ENA
ProteomicsRole of mTOR in regulating the extra cellular matrix
Explored the potential role of mTOR in regulating the extra cellular matrix of TGF-b1-stimulated IPF fibroblasts grown under macromolecular crowding conditions in the presence of either CZ415 or rapamycin
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD010164 | Pride
Cz415 Mtori Ipf fibroblasts 
GenomicsTranscriptomic and epigenetic profiling of fibroblasts in Idiopathic Pulmonary Fibrosis (IPF)
Transcriptomic and epigenetic profiling of fibroblasts in Idiopathic Pulmonary Fibrosis (IPF)
PRJNA747249 | ENA
TranscriptomicsTranslation value of the bleomycin rat model for the treatment of patients with Idiopathic Pulmonary Fibrosis (IPF)
Intratracheal application of bleomycin is known to induce inflammatory and fibrotic reactions in the lung within a short period of time and histological features include infiltration of inflammatory cells, collagen deposition and obliteration of alveolar spaces. Because some of these features are fo...
ORGANISM(S): Rattus norvegicus 
2014-10-28 | E-GEOD-48455 | biostudies-arrayexpress
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