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ProteomicsThe ARFGEF IQSEC1 is a targetable scaffold controlling collective cell invasion.
The signalling pathways underpinning cell growth and migration share overlapping components but what determines whether cells grow or move, when exposed to the same extrinsic signal, is unclear. We identify that in epithelial cancer cells cultured in extracellular matrix (ECM) these molecular functi...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD013810 | Pride
Epithelial cancer cells Prostate cancer Iqsec1 Growth and migration Gfp trap 
UnknownCalcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
Not available
S-EPMC7159923 | biostudies-literature
UnknownBi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.
Not available
S-EPMC6848997 | biostudies-literature
UnknownAn ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Not available
S-EPMC7955138 | biostudies-literature
UnknownBRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
Not available
S-EPMC3438945 | biostudies-literature
UnknownArtificial-Intelligence-Assisted Discovery of Genetic Factors for Precision Medicine of Antiplatelet Therapy in Diabetic Peripheral Artery Disease.
Not available
S-EPMC8773099 | biostudies-literature
UnknownGenetics of glucose homeostasis in pregnancy and postpartum.
Not available
S-EPMC12716172 | biostudies-literature
UnknownGenome-Wide Association Study of Motor Coordination.
Not available
S-EPMC8219980 | biostudies-literature
UnknownBRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3.
Not available
S-EPMC7252477 | biostudies-literature
UnknownSOX2 participates in spermatogenesis of Zhikong scallop Chlamys farreri.
Not available
S-EPMC6329761 | biostudies-literature
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