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GenomicsGenome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4
IRF5 and STAT4 are strongly associated with human systemic lupus erythematosus (SLE). By performing chromatin immunoprecipitation-sequencing (ChIP-Seq) in human peripheral blood mononuclear cells (PBMCs), we identified more than 7000 target genes for IRF5 and STAT4 in stimulated PBMCs. Contrarily, w...
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-38567 | biostudies-arrayexpress
ProteomicsProtein-tyrosine kinase 2-beta activates Interferon Regulatory Factor 5 to control inflammation
Interferon regulatory factor 5 (IRF5) plays a distinct role in the regulation of immune responses in health and disease and is a genetic risk factor several autoimmune conditions, including systemic lupus erythematosus, diabetes, arthritis and inflammatory bowel disease. IRF5 function as a transcrip...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-14 | PXD014033 | Pride
Pyk2 Irf5 
GenomicsGenome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells
Genome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells
PRJNA625322 | ENA
GenomicsRNA-sequencing of IRF5+ and IRF5- circulating monocytes from patients with Type-2 Diabetes
RNA-sequencing of IRF5+ and IRF5- circulating monocytes from patients with Type-2 Diabetes
PRJNA735395 | ENA
GenomicsIRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
PRJNA564499 | ENA
GenomicsIRF5 produced by kidney macrophages promotes polycystic kidney disease
IRF5 produced by kidney macrophages promotes polycystic kidney disease
PRJNA525686 | ENA
GenomicsGenome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells
Genetic variants in IRF5 are associated with multiple immune-mediated diseases. IRF5 has been predominantly focused on for its regulation of myeloid-derived cells. We found that IRF5 contributes to CD4+ T cell outcomes and that it regulates early T cell receptor-initiated signaling and subsequently ...
ORGANISM(S): Mus musculus 
2020-06-29 | GSE148672 | GEO
TranscriptomicsRNA-sequencing of IRF5+ and IRF5- circulating monocytes from patients with Type-2 Diabetes
Purpose: To characterise the transcriptomic landscape in monocytes associated with IRF5 expression Methods: RNA sequencing from FACS sorted IRF5+ and IRF5- CD14+ monocytes Results: Differential expression based on IRF5 postiivity provides insight into its roles in monocyte function and in type-2 dia...
ORGANISM(S): Homo sapiens 
2022-07-22 | GSE176216 | GEO
GenomicsOnco-exaptation of an Endogenous Retroviral LTR Drives IRF5 Expression in Hodgkin Lymphoma
The transcription factor interferon regulatory factor 5 (IRF5) is upregulated in Hodgkin lymphoma (HL) and a key regulator of the aberrant transcriptome characteristic of this disease. Here we show that IRF5 upregulation in HL is driven by transcriptional activation of a normally dormant endogenous ...
EGAS00001001205 | EGA
GenomicsGEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition
GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition
PRJNA523187 | ENA
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