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ProteomicsActivation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation
Pyk2 is a multidomain non-receptor tyrosine kinase that undergoes a complex, multi-stage activation process. Ca2+-flux induces conformational rearrangements that relieve autoinhibitory FERM domain interactions. The kinase domain phosphorylates a key linker residue to recruit Src kinase. Pyk2 and Src...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD034028 | Pride
Kinase Phosphorylation Hdx-ms 
GenomicsTargeting Pyk2 inhibition enhances bone restoration
Targeting Pyk2 inhibition enhances bone restoration
PRJNA1106770 | ENA
ModelsShin_2018_EGFR-PYK2-c-Met interaction network_model
Systems modelling of the EGFR-PYK2-c-Met interaction network predicted and prioritized synergistic drug combinations for Triple-negative breast cancer
2024-09-02 | BIOMD0000000826 | BioModels
GenomicsPyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
PRJNA665969 | ENA
ProteomicsProtein-tyrosine kinase 2-beta activates Interferon Regulatory Factor 5 to control inflammation
Interferon regulatory factor 5 (IRF5) plays a distinct role in the regulation of immune responses in health and disease and is a genetic risk factor several autoimmune conditions, including systemic lupus erythematosus, diabetes, arthritis and inflammatory bowel disease. IRF5 function as a transcrip...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-14 | PXD014033 | Pride
Pyk2 Irf5 
GenomicsPyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
PRJNA748756 | ENA
TranscriptomicsTargeting Pyk2 inhibition enhances bone restoration
Understanding the intricate cellular interactions involved in bone restoration is crucial for developing effective strategies to promote bone healing and mitigate conditions such as osteoporosis and fractures. Here, we provide compelling evidence supporting the anabolic effects of a pharmacological ...
ORGANISM(S): Homo sapiens 
2024-11-27 | GSE266328 | GEO
TranscriptomicsPyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
We demonstrated that Pyk2 is a novel fear memory suppressor molecule and Pyk2 null mice provide a model for understanding fear-related disorders.
ORGANISM(S): Mus musculus 
2022-02-02 | GSE180598 | GEO
TranscriptomicsPyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
We demonstrated that Pyk2 is a novel fear memory suppressor molecule and Pyk2 null mice provide a model for understanding fear-related disorders.
ORGANISM(S): Mus musculus 
2022-02-02 | GSE158606 | GEO
GenomicsThe AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
PRJNA701409 | ENA
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