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MetabolomicsHierarchical Carbon Metabolism in Iron-Deficient Bacteria Favors Iron-Scavenging Strategy

High-affinity iron (Fe) scavenging compounds, or siderophores, are widely employed by soil bacteria to survive scarcity in bioavailable Fe. Siderophore biosynthesis relies on cellular carbon metabolism, despite reported decrease in both carbon uptake and Fe-containing metabolic proteins in Fe-def...

2020-12-05 | MTBLS1715 | MetaboLights
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
TranscriptomicsTranscription profiling of rat duodenal samples at different developmental stages and the effects of iron-deficiency
The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages.
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1892 | biostudies-arrayexpress
TranscriptomicsIron (Fe) deficiency in Citrus
Transcription profiling of citrus rootstock Poncirus trifoliata (L.) Raf. Keywords: Abiotic stress (Iron chlorosis) Total RNA from four replicates for each sample category (Poncirus trifoliata (L.) Raf watered for 60 days with 18 uM Fe-EDDHA or without Fe-EDDHA) were generated and compared.
ORGANISM(S): Poncirus trifoliata 
2010-05-19 | E-GEOD-17255 | biostudies-arrayexpress
MetabolomicsAromatic amino acids metabolism shapes autophagy mediated adaptation to iron deprivation in glioma

GBM displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in glioma remains incompletely understood. DFO, an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of a...

2026-08-20 | MTBLS15394 | MetaboLights
TranscriptomicsRNA-seq of Arabidopsis root sieve element markers at 24h of iron deficiency
RNA-seq of pPEAR1::dBOX-YFP, pPEAR1-erGFP, and pC2-YFP to characterize the transcriptome associated with progressively more differentiated sieve elements. pPEAR1::dBOX-YFP is the proxy for early / phloem initials. pPEAR1-erGFP is the proxy for transit amplifying protophloem. pC2-YFP is the proxy for...
ORGANISM(S): Arabidopsis thaliana 
2025-11-21 | E-MTAB-15703 | biostudies-arrayexpress
TranscriptomicsThe metabolic responce to iron deficiency in Saccharomyces cerevisiae
Iron is an essential cofactor for enzymes involved in numerous cellular processes. We analyzed the metabolomes and transcriptomes of yeast grown in iron-rich and iron-poor media to determine which biosynthetic processes are altered when iron availability falls. Saccharomyces cerevisiae DBY7286 strai...
ORGANISM(S): Saccharomyces cerevisiae 
2009-11-12 | E-GEOD-19016 | biostudies-arrayexpress
ProteomicsProteomic dynamics in response to iron deficiency and hypoxia
Iron and oxygen deficiencies are common features in pathophysiological conditions such as is-chemia, neurological diseases, and cancer. Cellular adaptive responses to such deficiencies include repression of mitochondrial respiration as well as promotion of angiogenesis and cell cycle con-trol. We ap...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD030380 | Pride
Oxygen sensing Hippocampus Hypoxia Neu-ronal cells Iron deficiency Transcriptome analysis Quantitative proteomics 
TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42642 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CaCo-2 cells following various iron treatments
We investigated transcriptional response of CaCo-2 cells to iron treatments, we studied hemin effect by adding hemin to DMEM-FBS medium and iron deficiency effects in using an iron free medium compared to the same supplemented with FAC (ferric ammonium citrate). Experiment Overall Design: Biologica...
ORGANISM(S): Homo sapiens 
2008-01-19 | E-GEOD-3573 | biostudies-arrayexpress
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