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TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42642 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type and Hfe-/- mice with hereditary hemochromatosis subjected to dietary iron overload and treatment with nifedipine to reverse iron overload
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues leading to eventual organ failure. We have discovered a novel mechanism to reverse iron overload by pharmacological modulation of the dival...
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-982 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat duodenal samples at different developmental stages and the effects of iron-deficiency
The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages.
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1892 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of the human malaria parasite Plasmodium falciparum 3D7 cultured under different iron conditions
Background: Host iron deficiency is protective against severe malaria as the human malaria parasite Plasmodium falciparum depends on free iron from its host to proliferate. Due to the absence of transferrin, ferritin, ferroportin, and a functional heme oxygenase, the parasite’s essential pathways of...
ORGANISM(S): Plasmodium falciparum 
2024-04-08 | E-MTAB-13411 | biostudies-arrayexpress
TranscriptomicsM. sedula transcriptional response to ferrous iron and RISC supplements
Abstract: The crenarchaeal order Sulfolobales collectively contains at least five major terminal oxidase complexes. Based on genome sequence information, all five complexes are found only in Metallosphaera sedula and Sulfolobus tokodaii, the two sequenced Sulfolobales capable of iron oxidization. Wh...
ORGANISM(S): Metallosphaera sedula 
2008-10-22 | E-GEOD-12044 | biostudies-arrayexpress
TranscriptomicsBordetella bronchiseptica RB50 iron limitation 2
Bordetella bronchiseptica RB50 was shifted from iron replete to either iron depleted or iron replete media, and samples were taken post shift for transcriptional profiling
ORGANISM(S): Bordetella bronchiseptica 
2011-09-08 | E-MEXP-3076 | biostudies-arrayexpress
TranscriptomicsBordetella pertussis Tohama I iron limitation 1
B. pertussis Tohama I was grown in iron-depleted or iron-replete media and sampled at several time points to assess global gene expression
ORGANISM(S): Bordetella pertussis 
2011-09-08 | E-MEXP-3263 | biostudies-arrayexpress
TranscriptomicsFunctional Genomics Analysis of the Yeast Iron Responsive Transcription Factor Aft1 Reveals Iron-Independent Functions
The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low iron conditions. In addition, Aft1 has been implicated in numerou...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-01 | E-GEOD-20531 | biostudies-arrayexpress
TranscriptomicsDifferential expression of genes in the WT and hupB KO strain of Mycobacterium tuberculosis H37Rv upon iron limitation
HupB is a 28 kDa in Mycobacterium tuberculosis that is co-expressed with the siderophores mycobactin and carboxymycobactin upon iron limitation. High levels of all the three components are seen in low iron (LI; 0.02 M-BM-5g Fe / mL) organisms, with negligible expression in high iron organisms (HI; 8...
ORGANISM(S): Mycobacterium tuberculosis 
2014-03-18 | E-GEOD-53254 | biostudies-arrayexpress
TranscriptomicsIron regulation in P. syringae DC3000
DC3000 cultures were grown under highly controlled conditions and after the addition of iron citrate or sodium citrate to the media. In the cultures supplemented with iron, we found that cell-associated iron increased rapidly while culture densities were not significantly different over 4 hours when...
ORGANISM(S): Pseudomonas syringae pv. tomato str. DC3000 
2008-11-07 | E-GEOD-13500 | biostudies-arrayexpress
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