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MetabolomicsHierarchical Carbon Metabolism in Iron-Deficient Bacteria Favors Iron-Scavenging Strategy

High-affinity iron (Fe) scavenging compounds, or siderophores, are widely employed by soil bacteria to survive scarcity in bioavailable Fe. Siderophore biosynthesis relies on cellular carbon metabolism, despite reported decrease in both carbon uptake and Fe-containing metabolic proteins in Fe-def...

2020-12-05 | MTBLS1715 | MetaboLights
MetabolomicsClostridium bolteae suppresses Enterobacteriaceae expansion and restores gut microbiome homeostasis via disrupting siderophore-mediated iron acquisition

Intestinal inflammation and the related gut microbiome dysbiosis are becoming prevalent worldwide. Overgrowth of Enterobacteriaceae exacerbates intestinal inflammation and gut microbiome dysbiosis. Enterobacteriaceae secrets siderophore to acquire iron and survive in the iron-limited gut. Therefo...

2026-01-03 | MTBLS13592 | MetaboLights
TranscriptomicsIron uptake experiments in yeast
The budding yeast S. cerevisiae responds to depletion of iron in the environment by activating Aft1p, the major iron-dependent transcription factor, and by transcribing systems involved in the uptake of iron. Here we have studied the transcriptional response to iron deprivation, and have identified ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-07 | E-GEOD-4196 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis roots and shoots grown with or without iron
Iron-deficiency repsonses in Arabidopsis are controlled by several bHLH transcription factors. FIT, for example has been shown to direct iron-uptake responses. However, the role of shoot and root expressed genes bHLH100 and bHLH101 has not be clarified. We used microarray to study what genes migh...
ORGANISM(S): Arabidopsis thaliana 
2012-09-30 | E-GEOD-40076 | biostudies-arrayexpress
ProteomicsHow the presence of hemin affects the expression of all iron-uptake pathways in Pseudomonas aeruginosa cells
Iron is an essential nutriment for almost all organisms, but this metal is poorly bioavailable. During infection, bacteria access iron from the host by importing either iron or hemin. Pseudomonas aeruginosa, a Gram-negative pathogen, secretes two siderophores, pyoverdine (PVD) and pyochelin (PCH), t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2022-03-15 | PXD028818 | Pride
Pseudomonas Hemin Iron uptake pathway 
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type, ideR mutant and ideR complemented mutants strains grown in iron-sufficient or iron-deficient media
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-317 | biostudies-arrayexpress
TranscriptomicsRole of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-08 | E-GEOD-8732 | biostudies-arrayexpress
TranscriptomicsFunctional Genomics Analysis of the Yeast Iron Responsive Transcription Factor Aft1 Reveals Iron-Independent Functions
The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low iron conditions. In addition, Aft1 has been implicated in numerou...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-01 | E-GEOD-20531 | biostudies-arrayexpress
TranscriptomicsAft2 in yeast iron regulation
Iron homeostasis in the yeast Saccharomyces cerevisiae is regulated at the transcriptional level by Aft1p, which activates the expression of its target genes in response to low-iron conditions. The yeast genome contains a paralog of AFT1, which has been designated AFT2. To establish whether AFT1 and...
ORGANISM(S): Saccharomyces cerevisiae 
2005-08-13 | E-GEOD-3122 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of PAA short sequence-dependent regulation of bHLH104 in Arabidopsis thaliana iron homeostasis
Plants need iron but excess is harmful. Iron uptake transcription factor bHLH104 is negatively controlled by Fe-binding E3 ligase BTS. We show that three–amino acid terminal sequence of bHLH104 controls its breakdown by the BTS pathway. Removing PAA keeps bHLH104 active, driving constant iron uptake...
ORGANISM(S): Arabidopsis thaliana 
2026-09-18 | E-MTAB-16555 | biostudies-arrayexpress
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