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TranscriptomicsmRNA composition of IRP1 mRNPs in mouse tissues
Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation with IRP1 (iron regulatory protein 1). Reference Sanchez at al., 2007 Nat. Protoc. Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation ...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-17096 | biostudies-arrayexpress
ProteomicsIRP1 deficiency triggers metabolic reprograming, increases insulin sensitivity and protects mice against metabolic syndrome pathologies
Iron regulatory protein 1 (IRP1) is a post-transcriptional regulator of cellular iron metabolism. Irp1-/- mice are viable but develop polycythemia. We report that these animals also exhibit fasting hypoglycemia and are protected against high fat diet-induced hyperglycemia and liver steatosis. Mechan...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-17 | PXD051897 | Pride
Proteomics Irp1 Liver Mouse Insulin 
TranscriptomicsmRNA composition of IRP1 mRNPs in mouse tissues
Affymetrix microarrays were used to determine the mRNA composition of mRNPs obtained by immunoprecipitation with IRP1 (iron regulatory protein 1).
ORGANISM(S): Mus musculus 
2011-12-09 | GSE17096 | GEO
UnknownHuman IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner.
Not available
S-EPMC9502121 | biostudies-literature
ProteomicsIRP1 deficiency alters mitochondrial metabolism
Iron regulatory protein 1 (IRP1) is a post-transcriptional regulator of cellular iron metabolism. In mice, loss of IRP1 causes polycythemia through translational de-repression of hypoxia-inducible factor 2 (HIF2) mRNA, which increases renal erythropoietin production. Here we show that Irp1-/- mice d...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2026-01-13 | MSV000100449 | MassIVE
UnknownThe IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.
Not available
S-EPMC3612289 | biostudies-literature
UnknownDefective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.
Not available
S-EPMC7426581 | biostudies-literature
UnknownIRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2.
Not available
S-EPMC10374607 | biostudies-literature
UnknownA bulge uridine in the HIF2α IRE allows IRP1 but not IRP2 to selectively regulate HIF2α expression and ensuing EPO levels.
Not available
S-EPMC11826522 | biostudies-literature
UnknownIron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach.
Not available
S-EPMC10050399 | biostudies-literature
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