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TranscriptomicsCompounds profiling on MCF7
The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibi...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-19638 | biostudies-arrayexpress
TranscriptomicsCDK inhibitor PHA-793887 profiling on A2780
The effects of the CDK inhibitor PHA-793887 on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling. The A2780 cell line was treated with PHA-793887 (CDK-887) for 6 hours at a dose equal to 5 time the IC50. Untreated A2780 cells were used as a control. Two replic...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18498 | biostudies-arrayexpress
TranscriptomicsCDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line
The effects of the CDK inhibitor PHA-848125 (referred to as CDK-125) on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. The MCF7 cell line was treated with PHA-848125 for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a con...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18501 | biostudies-arrayexpress
TranscriptomicsFlavopiridol profiling on A2780
The effects of the CDK inhibitor Flavopiridol on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling. A2780 cells were treated with Flavopiridol for 6 hours at a dose equal to 5 times the IC50. Untreated A2780 cells were used as a control. Two replicates per tre...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18504 | biostudies-arrayexpress
TranscriptomicsCDK inhibitors PHA-848125 and PHA-690509 profiling on A2780
The effects of the CDK inhibitors PHA-848125 and PHA-690509 on the A2780 cell line were analysed by gene expression profiling. The A2780 cell line was treated with PHA-848125 (CDk-125) or PHA-690509 (CDk-509) for 6 hours at a dose equal to 5 times the IC50. Untreated A2780 cells were used as a contr...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18486 | biostudies-arrayexpress
TranscriptomicsTranscriptional pathway signatures for the Aurora inhibitor Danusertib
Treatment with Aurora inhibitors has been shown to induce diverse biological responses in different tumor cell lines, in part depending on their p53 status. To characterize at the transcriptional level the effects of Danusertib we analyzed by microarray different tumor cell lines, with WT or mutant ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-24547 | biostudies-arrayexpress
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