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TranscriptomicsTranscription profiling of mouse lung to investigate effects of ischemia reperfusion injury or nephrectomy
Experiments in rodents have shown that kidney ischemia/reperfusion injury (IRI) facilitates lung injury and inflammation. To identify potential ischemia-specific lung molecular pathways involved, we conducted global gene expression profiling of lung 6 or 36 hours following 1) bilateral kidney IRI, 2...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6730 | biostudies-arrayexpress
TranscriptomicsExpression data from an ex vivo ischaemia reperfusion model of renal deceased by cardiac death (DCD) donation in rat
In DCD organ donation one of the significant problems for the organ is the inflammatory response due to ischaemia reperfusion injury caused by warm ischaemia prior to retrieval followed by warm reoxygenation upon transplantation. We developed a model where a DCD kidney was retrieved and preserved us...
ORGANISM(S): Rattus norvegicus 
2012-03-22 | E-GEOD-36671 | biostudies-arrayexpress
TranscriptomicsGene expression profile in human orthotopic liver transplantation
We have studied the genes activated in human liver transplantation to identify potential target genes for the prevention or treatment of related injuries. In a first protocol, in order to evaluate the effect of Ischemia-Reperfusion Injury (IRI) on gene expression profile, we compared gene expressio...
ORGANISM(S): Homo sapiens 
2009-10-01 | E-GEOD-14951 | biostudies-arrayexpress
TranscriptomicsTLR4/NF-κB-responsive microRNAs in a mouse model of skeletal muscle ischemia-reperfusion injury
TLR4/NF-κB signaling plays a central mediator in response to danger signals released in the muscle ischemia-reperfusion injury (IRI). This study was designed to profile TLR4/NF-κB-responsive microRNAs (miRNAs) in the skeletal muscles following IRI. Following 2 h of ischemia and subsequent reperfus...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-47730 | biostudies-arrayexpress
TranscriptomicsIschemia reperfusion injury (IRI) in organ transplantation and the effects of carbon monoxide treatment
Ischemia reperfusion injury (IRI) in organ transplantation remains a significant problem with limited alternative therapeutic options. Organs that undergo significant damage during IRI, particularly those enduring long warm ischemia times, undergo significant delayed graft function (DGF) after reper...
ORGANISM(S): Sus scrofa 
2009-01-20 | E-GEOD-14373 | biostudies-arrayexpress
ProteomicsProteome analysis of membranes from renal ischemia-reperfusion injury mouse models.
Ischemia-reperfusion injury (IRI) is a well-known model for acute kidney injury (AKI). We applied proteomic analysis to detect membrane proteins from IRI mouse kidneys. The analysis set are composed of negative control (sham operation), samples of 4-hour after IRI, and samples of 8-hour IRI.
ORGANISM(S): Mus Musculus (mouse) 
2021-09-30 | PXD020708 | JPOST Repository
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
TranscriptomicsGene expression profiling in rat renal allografts after prolonged cold ischemia
Ischemia/reperfusion injury (IRI) has a major impact on the long-term outcome of renal allografts. However, the mechanisms of IRI related to chronic allograft nephropathy (CAN) are still poorly understood. To address this issue, in a F344 to Lewis transplantation model of the rat, kidneys were eithe...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-4441 | biostudies-arrayexpress
TranscriptomicsExpression data from a model of renal deceased by cardiac death (DCD) donation in rat
In DCD organ donation one of the significant problems for the organ is the inflammatory response due to ischaemiua reperfusion injury caused by warm ischaemia prior to retrieval followed by warm reoxygenation upon transplantation. We developed a model where a DCD kidney was retrieved and stoired ove...
ORGANISM(S): Rattus norvegicus 
2012-02-06 | E-GEOD-35555 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse contralateral kidneys in response to ischemia reperfusion injury
Current methods to analyze gene expression measure steady-state levels of mRNA. In order to specifically analyze mRNA transcription, a technique has been developed that can be applied in-vivo in intact cells and animals. The technique is referred with the acronym NIAC-NTR (Non Invasive Application a...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6698 | biostudies-arrayexpress
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