Ischemia reperfusion injury

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Organisms

Mus musculus (482)
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synthetic construct (8)
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Urocitellus parryii (2)
Mus (2)
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Oryctolagus cuniculus (1)
unidentified (1)
Acyrthosiphon pisum (1)
Caenorhabditis elegans (1)

Organisms

Mus musculus (411)
Rattus norvegicus (96)
Homo sapiens (61)
Sus scrofa (9)
unidentified (6)
Mus musculus musculus (3)
Rattus (3)
Sus scrofa domesticus (2)
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Urocitellus parryii (1)
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human gut metagenome (1)
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feces metagenome (1)
mouse gut metagenome (1)

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Tissue

Heart (19)
Kidney (14)
Brain (10)
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Epithelial cell (6)
Liver (5)
Stem cell (3)
Blood plasma (2)
Optic nerve (2)
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Electrically active cell (1)
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Macrophage (1)
Mesenchymal cell (1)
Muscle (1)
Neutrophil (1)
Skeletal muscle (1)
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Whole body (1)

Disease

Myocardial ischemia (9)
Acute kidney failure (3)
Cardiovascular system disease (3)
Ischemia (3)
Brain ischemia (2)
Ischaemia reperfusion injury (1)
Normal (1)
Heart injury (1)
Acute myocardial infarction (1)
Chronic kidney disease (1)
Coronary artery disease (1)
End stage renal disease (1)
Inflammation (1)
Wounds and Injuries (1)

Technology Type

Mass Spectrometry (74)
Shotgun proteomics (39)
Mass spectrometry (18)
Bottom-up proteomics (13)
Mass spectrometry assay (12)
Data-dependent acquisition (8)
Data-independent acquisition (8)
NMR spectroscopy (5)
Gel-based experiment (5)
Mass spectrometry imaging (2)
SWATH MS (2)
EI (1)
Affinity purification coupled with mass spectrometry proteomics (1)
Proteogenomics (1)
Top-down proteomics (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (12)
Liquid Chromatography MS - positive - reverse phase (12)
Liquid Chromatography MS - positive - reverse-phase (5)
NextSeq 500 (4)
Liquid Chromatography MS - negative - reverse-phase (4)
Liquid Chromatography MS - negative - hilic (4)
NextSeq 550 (3)
Illumina NovaSeq 6000 (2)
Orbitrap Fusion Lumos (2)
TripleTOF 6600 (2)
Illumina Stranded TruSeq RNA (1)
Agilent 2100 Bioanalyzer, Applied Biosystems 7900HT Sequence Detection System, Illumina TruSeq Small RNA Sample Preparation Kit (1)
RNeasy mini Kit, Ribo-Zero Human/Mouse/Rat kit (1)
Agilent G2565BA Microarray Scanner System (Agilent Technologies) (1)
Tecan HS4800 hybridization station (Tecan) (1)
Agilent 2100 Bioanalyzer (1)
ScanArray Express HT [PerkinElmer] (1)
Illumina NovaSeq X (1)
Illumina HiSeq 2500 (1)
Illumina HiSeq 2000 (1)
Illumina HiSeq 3000 (1)
Illumina HiSeq 4000 (1)
Bruker timsTOF Pro (1)
LTQ Orbitrap Elite (1)
LTQ Orbitrap Velos (1)
Orbitrap Fusion (1)
Q Exactive (1)
Q Exactive HF-X (1)
TripleTOF 5600 (1)
ZenoTOF 7600 (1)

Publication Date

2026 (130)
2025 (121)
2024 (103)
2023 (80)
2022 (60)
2021 (50)
2019 (46)
2020 (34)
2010 (30)
2016 (27)
2015 (22)
2014 (21)
2011 (16)
2013 (15)
2017 (14)
2012 (11)
2008 (11)
2018 (11)
2009 (8)
2007 (8)
2006 (2)
2005 (1)

UNIPROT ID/AC

A0A024RAN2 (1)
A0A087WT59 (1)
A0A087WTX5 (1)
A0A087WVW2 (1)
A0A087WWA5 (1)
A0A087WYL9 (1)
A0A087X130 (1)
A0A087X1V9 (1)
A0A087X232 (1)
A0A0A0MS07 (1)
A0A0A0MS51 (1)
A0M8Q6 (1)
A1A5B4 (1)
A1L4H1 (1)
A2BFH1 (1)
A2NUT2 (1)
A4F255 (1)
A5A3E0 (1)
A6NNZ2 (1)
B1AHL2 (1)
B1AP13 (1)
B3KML9 (1)
B4DHB3 (1)
B4DPR2 (1)
B4DRF2 (1)
B4DRV9 (1)
B4DY08 (1)
B4E3A4 (1)
B4E3S6 (1)
B7Z556 (1)

ENSEMBL ID

ENSG00000170477 (1)
ENSG00000229353 (1)

CHEBI ID

CHEBI:16919 (8)
CHEBI:16704 (7)
CHEBI:17368 (7)
CHEBI:17596 (7)
CHEBI:16335 (6)
CHEBI:17568 (6)
CHEBI:15756 (6)
CHEBI:7916 (6)
CHEBI:16708 (6)
CHEBI:15891 (6)
CHEBI:17154 (6)
CHEBI:17191 (6)
CHEBI:16737 (6)
CHEBI:17203 (6)
CHEBI:16414 (6)
CHEBI:18019 (6)
CHEBI:15354 (6)
CHEBI:17821 (5)
CHEBI:18257 (5)
CHEBI:16196 (5)
CHEBI:15603 (5)
CHEBI:17895 (5)
CHEBI:16750 (5)
CHEBI:16235 (5)
CHEBI:18211 (5)
CHEBI:16828 (5)
CHEBI:30769 (5)
CHEBI:17562 (5)
CHEBI:16027 (5)
CHEBI:15741 (5)

Metabolite Name

Creatinine (13)
Creatine (11)
Thymine (10)
Adenosine (10)
L-Valine (9)
L-Lysine (9)
Adenine (9)
Taurine (9)
Inosine (9)
Hypoxanthine (9)
Choline (9)
Betaine (9)
Uridine (9)
L-Proline (8)
Cytosine (8)
Uracil (8)
L-Isoleucine (7)
L-Tryptophan (7)
L-Histidine (7)
Palmitic acid (7)
L-Tyrosine (7)
Ornithine (7)
Guanine (7)
Pantothenic acid (7)
Niacinamide (6)
Sphingosine (6)
1-Methylhistidine (6)
Cytidine (6)
L-Phenylalanine (6)
L-Leucine (6)

First Public Date

2024 (145)
2026 (142)
2025 (132)
2023 (81)
2022 (68)
2014 (51)
2021 (47)
2019 (40)
2020 (39)
2017 (13)
2015 (11)
2018 (8)
2016 (7)
2013 (3)

Modelling Approach

Mathematical model (1)
Ordinary differential equation model (1)

Lab affiliation

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (3)
College of Biology, Hunan University, China (2)
Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany; CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany (2)
Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China (2)
Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (2)
Hubei University of Medicine, Taihe Hospital (2)
King's College London - Cardiovascular Division (2)
Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, Sweden (2)
1) Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany 2) CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands (1)
Biomolecular Mass Spectrometry and Proteomics, BijvoetCenter for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands (1)
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA (1)
Charles Perkins Centre, University of Sydney (1)
Chengdu University of Traditional Chinese Medicine (1)
Cornell University (1)
Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne; CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany (1)
Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China. (1)
Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. (1)
Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, USA. (1)
Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA (1)
Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China (1)
Department of Pharmacology, Harbin Medical University, Heilongjiang 163319, China (1)
Department of Surgery, Maastricht University, Maastricht (1)
Departments of Medicine (Division of Cardiology), Virginia Commonwealth University, Richmond, VA, 23298 (1)
Fondazione Ri.Med Department of Laboratory Medicine and Advanced Biotechnologies, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS - ISMETT) Via Ernesto Tricomi, 5 - 90127 Palermo (1)
Functional Proteomics Lab. Life Sciences Dept., University of Siena Siena, Italy (1)
ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. Da República, 2780-157 Oeiras, Portugal;iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901, Oeiras , Portugal (1)
ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal; iBET- Instituto de Biologia Experimental e Tecnológica, Apartado 12 2780-901 Oeiras, Portugal (1)
Institute of Biochemistry II, Goethe University Medical School, Frankfurt am Main, Germany (1)
Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology (1)

IsPrivate

False (2)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (82)
RNA-seq of coding RNA (9)
Unknown experiment type (6)
Transcription profiling by RT-PCR (3)
Animal - High-throughput sequencing (2)
Animal - One-color microarray (1)
Animal - Single-cell sequencing (1)
High-throughput sequencing (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
ChIP-seq (1)
Proteomic profiling by array (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (670)
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2020 (468)
2019 (341)
2018 (293)
2017 (291)
2016 (244)
2015 (216)
2014 (158)
2013 (120)
2026 (115)
2012 (104)
2011 (83)
2010 (80)
2009 (48)
2008 (34)
2007 (21)
2006 (16)
2005 (10)
2004 (5)
2003 (3)
2002 (3)
1997 (2)
2000 (1)

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The dynamic changes and mechanism of no reflow injury after myocardial ischemia-reperfusion

This study aims to investigate the dynamic changes and correlation of no-reflow (NR) injury following myocardial ischemia and reperfusion, and to explore the underlying mechanism of NR injury through transcriptomic and metabolomic analysis. Methods: Healthy male SD rats were divided into two batches...

2026-08-25 | MTBLS15452 | MetaboLights

Mongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights

Untargeted liver metabolomic profiling of hepatocyte-specific Serpine2-knockout mice following ischemia-reperfusion injury

Untargeted metabolomics was performed to investigate hepatic metabolic changes associated with hepatocyte-specific Serpine2 deletion after ischemia-reperfusion injury. Eight liver samples were collected from Serpine2-floxed control mice (NC) and hepatocyte-specific Serpine2-knockout mice (HKO), with...

2026-10-11 | MTBLS15998 | MetaboLights

Intraoperative intestinal ischemia-reperfusion injury aggravates postoperative delirium by remodeling gut microbiota

Postoperative delirium, is a notable and serious complication after surgery, commonly extending hospitalization by 2-3 days. In a cohort of 167 patients, elevated serum intestinal fatty acid binding protein (I-FABP) was identified as an independent risk factor for postoperative delirium. Complementa...

2026-03-30 | MTBLS14186 | MetaboLights

B-cell Translocation Gene 2 Inhibits UFMylation Modification of FMO1 thus Restricting Taurine Synthesis and Exacerbating Ferroptosis in Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion (I/R) injury is a common complication occurs during liver transplantation. However, the mechanisms underlying hepatic I/R injury have not been fully elucidated. B-cell translocation gene 2 (Btg2) has been implicated in the development of various diseases. However, its...

2026-03-07 | MTBLS11677 | MetaboLights

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...

2019-09-20 | MTBLS1085 | MetaboLights

Integrated transcriptomic and metabolomic analysis reveals the regulatory role of Itaconic acid in inflammatory infiltration during myocardial Ischemia-Reperfusion injury

Following establishment of a myocardial ischemia-reperfusion model, tissue samples from the infarct border zone were harvested for transcriptomics and wide-target metabolomic sequencing. Bioinformatics methods were used to analyse the transcriptomics and metabolomics results separately and to per...

2025-10-14 | MTBLS12934 | MetaboLights

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo mouse model.

This SuperSeries is composed of the following subset Series: GSE23160: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model. GSE23162: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model. Refer to ...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23163 | biostudies-arrayexpress

Functional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.

Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress

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