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ProteomicsGlobal Interferon-stimulated Genes Interactome Network
Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecul...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012274 | Pride
Isg interactome Ifn Ap-lc-ms/ms 
ProteomicsFluAV vRNP interactome - A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecul...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012275 | Pride
Influenza Rnps Fluav Ap-lc-ms/ms 
GenomicsInteractome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
PRJNA830877 | ENA
TranscriptomicsInteractome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
Purpose: Cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex CRL4CRBN, is the target of the small molecules lenalidomide (Len) and avadomide (Ava). Upon binding of the drugs, Aiolos and Ikaros are recruited to the E3 ligase, ubiquitylated and subsequently degraded. In DLBCL cell...
ORGANISM(S): Homo sapiens 
2022-07-12 | GSE201324 | GEO
UnknownInteractome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL.
Not available
S-EPMC9662945 | biostudies-literature
UnknownDynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling.
Not available
S-EPMC11148166 | biostudies-literature
UnknownRestriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense.
Not available
S-EPMC8939003 | biostudies-literature
OtherInhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [PRO-Seq]
The lysine acetyltransferase (KAT) activity of p300/CREBBP has traditionally been linked to transcriptional activation. This has been attributed largely to acetylation of histone residues such as H3K27ac, a defining hallmark of active regulatory elements. Here we show that, in acute myeloid leukemia...
ORGANISM(S): Homo sapiens 
2026-02-27 | GSE304020 | GEO
TranscriptomicsInhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [SLAM-Seq]
The lysine acetyltransferase (KAT) activity of p300/CREBBP has traditionally been linked to transcriptional activation. This has been attributed largely to acetylation of histone residues such as H3K27ac, a defining hallmark of active regulatory elements. Here we show that, in acute myeloid leukemia...
ORGANISM(S): Homo sapiens 
2026-02-27 | GSE304253 | GEO
OtherInhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [CRISPR-Screens]
The lysine acetyltransferase (KAT) activity of p300/CREBBP has traditionally been linked to transcriptional activation. This has been attributed largely to acetylation of histone residues such as H3K27ac, a defining hallmark of active regulatory elements. Here we show that, in acute myeloid leukemia...
ORGANISM(S): Homo sapiens 
2026-02-27 | GSE304740 | GEO
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