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TranscriptomicsDifferential gene expression in GBS6 cells after EWS-POU5F1 knockdown
Our objective is to clarify the function of EWS-POU5F1 chimera. Specifially, GBS6 cells were established from an undifferentiated bone sarcoma carrying translocation t(6;22)(p21;q12). The translocation resulted in a gene fusion between EWS and POU5F1. Gene expression analysis of t(6;22) undifferenti...
ORGANISM(S): Homo sapiens 
2009-05-31 | E-GEOD-12320 | biostudies-arrayexpress
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells [mRNA data]
'MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular re...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30131 | biostudies-arrayexpress
ProteomicsThe structure and symmetry of the Radial Spoke protein complex in Chlamydomonas flagella
Chemical cross-linking coupled to mass spectrometry was used to study the organization of the Radial Spoke protein complex from Chlamydomonas. Experiments were performed by on-bead cross-linking of the immobilized complex with the amine-reactive cross-linking reagent disuccinimidyl suberate (DSS).
ORGANISM(S): Chlamydomonas reinhardtii 
2020-08-07 | PXD015658 | Pride
Chemical cross-linking  dss  structural proteomics  radial spoke complex 
TranscriptomicsExpression profiles of X-ray responsive miRNA in human cells [miRNA data]
MicroRNA (miRNA) is a type of non-coding RNA that regulates the expression of its target genes by interacting with the complementary sequence of the target mRNA molecules. Recent evidence has shown that genotoxic stress induces miRNA expression, but the target genes involved and role in cellular res...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-30130 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
TranscriptomicsCharacterization of transcription patterns of bacteriophage fRSL1 genes during infection cycle.
fRSL1 is a jumbo myovirus stably and lytically infecting the phytopathogenic bacterium Ralstonia solanacearum. In this study, we investigate the infection cycle of fRSL1 and provide a genomic, proteomic and transcriptomic view of this phage. Its 231-kbp genome sequence showed many genes lacking dete...
ORGANISM(S): Ralstonia solanacearum 
2010-07-21 | E-GEOD-23017 | biostudies-arrayexpress
TranscriptomicsRadiation-induced genes expressed in two murine tumors.
Gene expression profiling was used to identify genes that display radiation-induced transcriptional change over tumor histopathology. Keywords: mouse squamous cell carcinoma, fibrosarcoma and mammary carcinoma, gamma-irradiation, carbon ion irradiation, resected sample, transplanted tissues C3H/He...
ORGANISM(S): Mus musculus 
2009-03-20 | E-GEOD-5331 | biostudies-arrayexpress
ProteomicsMDCK Culture Medium
The SILAC analysis of secreted proteins in monoculture or mix-culture of normal and transformed cells
ORGANISM(S): Cellular Organisms 
2018-11-14 | PXD008209 | JPOST Repository
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