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MetabolomicsSmall auxin-up RNA promotes GmMYB176 gene transcription to modulate soybean isoflavone content

Isoflavones have been widely studied because of their potential health benefits, including antioxidant, anti-inflammatory, and anticancer properties. Soybeans (Glycine max (L.) Merr) are an effective source of natural isoflavones in humans. Therefore, it is important to cultivate varieties showin...

2025-06-23 | MTBLS12627 | MetaboLights
TranscriptomicsGenome-wide analysis of gene expression in isoflavone and 3,3’-diindolylmethane treated C4-2B prostate cancer cells
Expression profiling of isoflavone and 3,3’-diindolylmethane treated C4-2B prostate cancer cells was conducted using Affymetrix Human Genome U133 Plus 2.0. Array C4-2B prostate cancer cells were treated with isoflavone and B-DIM for 6 hours or longer up to 72 hours. Gene expression profiling was con...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-35324 | biostudies-arrayexpress
TranscriptomicsThe effect of dietary soybeans and their isoflavone content on the expression profiles of mRNAs in liver of rats
Soyfoods have been drawn the interrest in the roles that reducing risk of cardiovascular disease. Among various components, isoflavones have been come to the attention as beneficial soy ingredients. To evaluate the effectiveness of isoflavone content in dietary soybean (Glycine max) on modulating li...
ORGANISM(S): Rattus norvegicus 
2016-08-01 | E-GEOD-67782 | biostudies-arrayexpress
TranscriptomicsTofu decreases serum lipid levels and modulates hepatic gene expression involved in lipid metabolism in rats
The effects of freeze-dried tofu, a traditional Japanese soy food, were compared with those of major active soy components, protein and isoflavone, by observing physiological differences and global transcriptomes in the liver of male rats. The GeneChip data was normalized and summarized by using Sup...
ORGANISM(S): Rattus norvegicus 
2011-08-26 | E-GEOD-23748 | biostudies-arrayexpress
TranscriptomicsA comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver
Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. The GeneChip data was normalized and summarized by using SuperNORM data service (Skylight Biotech Inc.). Significance of expressional change among groups...
ORGANISM(S): Rattus norvegicus 
2012-10-10 | E-GEOD-41420 | biostudies-arrayexpress
TranscriptomicsEffect of isoflavone agonists of IRF-3 on response to RNA viruses
There is a growing need for novel antiviral therapies that are broad-spectrum, effective, and not subject to resistance due to viral mutations. Using high-throughput screening methods, including computational docking studies and an ISG54-luciferase reporter assay, we identified a class of isoflavone...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-GEOD-38016 | biostudies-arrayexpress
GenomicsSoy Isoflavone Improves Reproductive Performance and Antioxidant Capacity of Sows and Reshapes Colostrum-Derived Exosomal microRNA Profiles
Soy Isoflavone Improves Reproductive Performance and Antioxidant Capacity of Sows and Reshapes Colostrum-Derived Exosomal microRNA Profiles
PRJNA1452794 | ENA
UnknownLarge inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessment.
Not available
S-EPMC4197455 | biostudies-literature
GenomicsSoy Isoflavone Improves Reproductive Performance and Antioxidant Capacity of Sows and Reshapes Colostrum-Derived Exosomal microRNA Profiles
Background: This study investigated the effects of dietary soy isoflavone supplementation on reproductive performance, antioxidant capacity, and colostrum-derived exosomal microRNA profiles in sows, with the aim of exploring the molecular basis of maternal–offspring integrated regulation. A total of...
ORGANISM(S): Sus scrofa 
2026-04-16 | GSE327773 | GEO
TranscriptomicsGenome-wide analysis of gene expression in isoflavone and 3,3’-diindolylmethane treated C4-2B prostate cancer cells
Expression profiling of isoflavone and 3,3’-diindolylmethane treated C4-2B prostate cancer cells was conducted using Affymetrix Human Genome U133 Plus 2.0. Array
ORGANISM(S): Homo sapiens 
2012-01-25 | GSE35324 | GEO
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