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ProteomicsA Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells
Natural systems produce various γ-dicarbonyl-bearing compounds that can covalently modify lysine in protein targets via the classic Paal-Knorr reaction. Among them is a unique class of lipid-derived electrophiles - isoketals that exhibit high chemical reactivity and critical biological functions. Ho...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-15 | PXD028270 | Pride
Paal-knorr reaction Isoketals Chemoproteomics Onayne 
UnknownA Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells.
Not available
S-EPMC8580055 | biostudies-literature
TranscriptomicsEffect of Hypertension of Dendritic Cell Gene Expression
Oxidative injury and inflammation have been implicated in the genesis of hypertension but the mechanisms involved are not fully understood. We describe a new pathway in which angiotensin II promotes dendritic cell (DC) activation of T cells and ultimately hypertension. NADPH oxidase-dependent super...
ORGANISM(S): Mus musculus 
2014-07-16 | E-GEOD-59422 | biostudies-arrayexpress
UnknownDC isoketal-modified proteins activate T cells and promote hypertension.
Not available
S-EPMC4220659 | biostudies-literature
TranscriptomicsEffect of Hypertension of Dendritic Cell Gene Expression
Oxidative injury and inflammation have been implicated in the genesis of hypertension but the mechanisms involved are not fully understood. We describe a new pathway in which angiotensin II promotes dendritic cell (DC) activation of T cells and ultimately hypertension. NADPH oxidase-dependent supero...
ORGANISM(S): Mus musculus 
2014-07-16 | GSE59422 | GEO
UnknownScavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7.
Not available
S-EPMC5032694 | biostudies-literature
UnknownReactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis.
Not available
S-EPMC2903647 | biostudies-literature
GenomicsMus musculus
Effect of Hypertension of Dendritic Cell Gene Expression
PRJNA255282 | ENA
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