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ProteomicsA Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells
Natural systems produce various γ-dicarbonyl-bearing compounds that can covalently modify lysine in protein targets via the classic Paal-Knorr reaction. Among them is a unique class of lipid-derived electrophiles - isoketals that exhibit high chemical reactivity and critical biological functions. Ho...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-15 | PXD028270 | Pride
Paal-knorr reaction Isoketals Chemoproteomics Onayne 
UnknownA Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells.
Not available
S-EPMC8580055 | biostudies-literature
ProteomicsA Quantitative Chemoproteomics Platform to Interrogate Metabolic Activation of Furan-Containing Herbal Medicines
In this work, we extend our previously reported clickable γ-dicarbonyl probe ONAyne to exogenous natural products and establish a competitive activity-based protein profiling (ABPP) platform for furan-containing herbal constituents. In mouse liver microsomes, the platform captured, at site level and...
ORGANISM(S): Acyrthosiphon Pisum 
2026-09-12 | PXD084125 |
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