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ProteomicsThe iron-regulated sRNA IsrR is involved in the display of full Staphylococcus aureus virulence in part via SaeRS activation
The Gram-positive pathogenic bacterium Staphylococcus aureus permanently colonizes the nasal mucosa in about 30% of the healthy population. However, as an opportunistic pathogen, S. aureus can also cause a variety of diseases, the treatment of which is becoming increasingly difficult due to antibiot...
ORGANISM(S): Staphylococcus aureus 
2025-04-11 | PXD055092 | Pride
Saers Virulence Staphylococcus aureus Secretome Isrr 
ProteomicsExploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in Staphylococcus aureus
As integral parts of gene regulatory networks, small regulatory RNAs (sRNAs) play important roles in the adaptation of bacteria to environmental conditions. To adapt to iron limitation, many bacteria exploit an "iron-sparing" response mediated by Fur-regulated sRNAs such as RyhB of E. coli, allowing...
ORGANISM(S): Staphylococcus aureus 
2024-07-12 | PXD045218 | Pride
Hg001 Iron limitation Staphylococcus aureus Iron sparing response Isrr 
GenomicsMS2-affinity purification coupled with RNA sequencing (MAPS) reveals S. aureus IsrR sRNA targetome
MS2-affinity purification coupled with RNA sequencing (MAPS) reveals S. aureus IsrR sRNA targetome
PRJNA1258230 | ENA
TranscriptomicsMS2-affinity purification coupled with RNA sequencing (MAPS) reveals S. aureus IsrR sRNA targetome
Bacterial regulatory RNAs (sRNAs) are commonly short non-coding RNAs that function as pleiotropic regulators by post-transcriptionally impacting mRNA stability and/or translation. They play significant roles in bacterial physiology and are typically expressed in response to specific environmental st...
ORGANISM(S): Staphylococcus aureus 
2025-10-02 | GSE296222 | GEO
UnknownThe Staphylococcus aureus non-coding RNA IsrR regulates TCA cycle activity and virulence.
Not available
S-EPMC11879123 | biostudies-literature
UnknownIndole Sensing Regulator (IsrR) Promotes Virulence Gene Expression in Enteric Pathogens.
Not available
S-EPMC9426417 | biostudies-literature
UnknownThe <i>Staphylococcus aureus</i> small non-coding RNA IsrR regulates TCA cycle activity and virulence.
Not available
S-EPMC11245030 | biostudies-literature
UnknownExploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in Staphylococcus aureus.
Not available
S-EPMC11257911 | biostudies-literature
UnknownThe iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in <i>Staphylococcus aureus</i>.
Not available
S-EPMC12607789 | biostudies-literature
GenomicsStaphylococcal aconitase expression during iron deficiency is controlled by an sRNA-driven feedforward loop and moonlighting activity
Transcriptomic response to the absence of IsrR sRNA and aconitase RNA-binding activity under iron-depleted growth conditions
PRJEB74242 | ENA
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