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TranscriptomicsDevelopmental timecourse of mouse ocular lens and whole embryo control
Identification of genes involved in ocular birth defects remains a challenge. To facilitate the identification of genes associated with cataract, we developed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE contains microarray gene express...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32334 | biostudies-arrayexpress
UnknowniSyTE: integrated Systems Tool for Eye gene discovery.
Not available
S-EPMC3339920 | biostudies-literature
UnknowniSyTE 2.0: a database for expression-based gene discovery in the eye.
Not available
S-EPMC5753381 | biostudies-literature
TranscriptomicsAnalysis of temporal lens gene expression microarrays to expand the eye gene discovery tool iSyTE
Purpose: While the bioinformatics gene-discovery tool iSyTE (integrated Systems Tool for Eye gene discovery) has proved effective in identifying new cataract-linked genes, it primarily depended on lens-enriched expression of just three wild-type mouse embryonic stages. To increase iSyTE’s efficacy, ...
ORGANISM(S): Mus musculus 
2017-09-21 | GSE100136 | GEO
ProteomicsProteomic profiling of embryonic retina to facilitate ocular disease gene discovery
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefor...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD039490 | Pride
Gene discovery Proteome Embryogenesis Retina Mass spectrometry Isyte Development 
TranscriptomicsDevelopmental timecourse of mouse ocular lens and whole embryo control
Identification of genes involved in ocular birth defects remains a challenge. To facilitate the identification of genes associated with cataract, we developed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE contains microarray gene express...
ORGANISM(S): Mus musculus 
2012-02-16 | GSE32334 | GEO
GenomicsMus musculus
Analysis of temporal lens gene expression microarrays to expand the eye gene discovery tool iSyTE
PRJNA390783 | ENA
TranscriptomicsHigh-throughput RNA-sequencing-based transcriptomic profiles of embryonic lens development for cataract gene discovery
We applied previously established in silico whole-embryo body (WB)-subtraction-based approach to identify “lens-enriched” genes. These new RNA-seq datasets on embryonic stages E10.5, E12.5, E14.5 and E16.5 confirmed high expression of established cataract-linked genes and identified several new pote...
ORGANISM(S): Mus musculus 
2019-01-08 | GSE119596 | GEO
UnknownMS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Not available
S-EPMC6983357 | biostudies-literature
UnknownProteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery.
Not available
S-EPMC10680127 | biostudies-literature
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