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TranscriptomicsTranscription profiling of mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
Type 2 diabetes is a complex disorder due to defects in insulin secretion and insulin action. Therefore, we investigated mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT) have reduced amount of white adipose tissue, high basal metabolic rate, improved glucose tolerance, high insul...
ORGANISM(S): Mus musculus 
2007-04-25 | E-MEXP-165 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of primary prostate cancer biopsies wutg different ETS transcription factor rearrangements
This work was conducted to identify shared and specific target genes of different ETS transcription factor rearrangements in prostate cancer. Potential target genes were identified by differential gene expression analysis of primary tumor samples with ETS rearrangements, and validated by ETS silenci...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-42954 | biostudies-arrayexpress
TranscriptomicsExpression of Splicing Factor Genes is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis
Alternative mRNA splicing provides transcript diversity and has been proposed to contribute to several human diseases. Here, we demonstrate that expression of genes regulating RNA processing is decreased in both liver and skeletal muscle of obese humans. To determine the metabolic impact of reduced ...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-22435 | biostudies-arrayexpress
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