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TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN BRONCHIAL TISSUE CULTURES
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5179 | biostudies-arrayexpress
TranscriptomicsA 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysema following smoking cessation or switching to e-vapor products.
Cigarette smoking causes serious diseases, including lung cancer, heart disease, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine containing products may reduce disease risks among those unabl...
ORGANISM(S): Mus musculus 
2021-03-18 | E-MTAB-9597 | biostudies-arrayexpress
UnknownSingle-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon.
Not available
S-EPMC8741728 | biostudies-literature
UnknownDysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.
Not available
S-EPMC7156348 | biostudies-literature
ProteomicsProteogenomics of adenosine-to-inosine RNA editing in fruit fly
This dataset is a part of a bigger work on RNA editing in D. melanogaster brain. We present Orbitrap spectra searched against a customized database of Drosophila proteome with introduction of variants provided by RNA editing. Three files reflect 3 technical replicates.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-25 | PXD009590 | Pride
Rna editing Proteogenomics Drosophila melanogaster 
ProteomicsExperimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
In this study, we developed a model system for the assessment of small molecule-protein interactions using intact cells treated with a commercially available highly specific mitogen-activated protein kinase (MEK) 1/2 inhibitor to prepare a set of unfractionated test samples labeled with tandem mass ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034087 | Pride
Cetsa Mass spectrometry Tpp Target identification Thermal stability assays Drug-protein interactions 
TranscriptomicsA comparison of mono-culture and co-culture model containing fibroblasts
Organotypic three dimensional cultures of epithelial cells are grown at the air–liquid interface (ALI) and resemble the in vivo counterparts. Although the complexity of in vivo cellular responses could be better manifested in co-culture models in which additional cell-types such as fibroblasts were ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-MTAB-3462 | biostudies-arrayexpress
TranscriptomicsCombined Chronic Toxicity and Carcinogenicity of Aerosol from a Heated Tobacco Product (mRNA data)
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus 
2020-08-17 | E-MTAB-8540 | biostudies-arrayexpress
ProteomicsProteomic analysis of protein profile of blood serum of patients with autism children
A comparative panoramic mass spectrometric analysis of serum samples from three families with children with autistic disorders was carried out. The total number of examined samples was nine, including four control samples from healthy parents, and five samples from autistic children.
ORGANISM(S): Homo sapiens (Human) 
2016-11-01 | PXD005193 | Pride
Autism Esi-ms/ms 
UnknownDendrons and Dendritic Terpolymers: Synthesis, Characterization and Self-Assembly Comparison.
Not available
S-EPMC7766238 | biostudies-literature
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