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TranscriptomicsIntestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue o...
ORGANISM(S): Drosophila melanogaster 
2017-09-23 | E-MTAB-6056 | biostudies-arrayexpress
TranscriptomicsMeasuring ageing-dependent transcriptional responses to human Aβ42 peptide in Drosophila brain
We have shown previously that older flies are intrinsically more susceptible to Aβ42 toxicity. Building upon these findings, this study aimed to determine the mechanisms by which ageing increases this vulnerability to damage in the brain. A fixed dose of Aβ42 peptide was induced in young (5d) versus...
ORGANISM(S): Drosophila melanogaster 
2021-04-07 | E-MTAB-8865 | biostudies-arrayexpress
TranscriptomicsRegulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein interaction domains, thus playing a critical role in signal transduc...
ORGANISM(S): Drosophila melanogaster 
2016-03-30 | E-MTAB-4612 | biostudies-arrayexpress
TranscriptomicsCell-type-specific modulation of longevity by Forkhead family transcription factors in the Drosophila nervous system
We previously found that the Drosophila FoxA transcription Fork Head (FKH) is necessary for reduced insulin signalling to extend lifespan. We have now identified that increased expression of FKH in neurons alone is sufficient to extend healthy lifespan. We carried out RNA-sequencing in head tissue o...
ORGANISM(S): Drosophila melanogaster 
2021-02-03 | E-MTAB-9017 | biostudies-arrayexpress
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
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