Sort   by:  
 Page size 
TranscriptomicsDynamic mRNA Expression analysis of cells undergoing synchronous life-cycle differentiation in Trypanosoma brucei
mRNA expression profiles of trypanosomes from two discrete bloodstream form stages of the parasite (slender and stumpy forms), as well as during the transition of the stumpy population to the procyclic life-cycle stage were studied. Our analysis represents the first comparison of in vivo derived ple...
ORGANISM(S): Trypanosoma brucei 
2010-05-16 | E-GEOD-17026 | biostudies-arrayexpress
TranscriptomicsDiversity in the polyadenylation and decay of human cellular microRNAs during Vaccinia virus infection
Vaccinia virus (VACV) is a large cytoplasmic dsDNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. Here we use small RNA sequencing to comprehensively quantify the impact of VACV infection on the expression of endogenous small non-coding RNAs (sncRNAs)...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-54235 | biostudies-arrayexpress
TranscriptomicsRegulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development within the mammalian bloodstream as they progress from morphologically M-bM...
ORGANISM(S): Trypanosoma brucei brucei 
2013-12-16 | E-GEOD-46388 | biostudies-arrayexpress
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
TranscriptomicsRNAi of TbNMD3 in procyclic form Trypanosoma brucei lines
A procyclic form Trypansome brucei RNAi line (PTT parental line, transfected with pALC14 incorporating a TbNMD3 gene fragment) capable of inducing depletion of TbNMD3 was analysed for mRNA expression by RNAseq Cells were grown for 72 hours in culture; RNAi was induced in cells by the addition of 1 m...
ORGANISM(S): Trypanosoma brucei brucei 
2015-04-28 | E-GEOD-67246 | biostudies-arrayexpress
TranscriptomicsModulation of murine bone marrow derived dendritic cells by IL-4
The archetypal Th2 cytokine interleukin 4 (IL-4) has previously been shown to alternatively activate dendritic cells (DCs) both in vitro and in vivo.To more fully understand the impact of IL-4 dependent alternative activation of DCs, we used mRNA microarrays to define their transcriptional profile. ...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-59868 | biostudies-arrayexpress
TranscriptomicsExosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Litomosoides sigmodontis 
2014-11-25 | E-GEOD-60022 | biostudies-arrayexpress
TranscriptomicsExosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system [Litomosoides sigmodontis]
In mammalian systems, extracellular small RNAs can operate in a paracrine manner to communicate information between cells, relying on transport within vesicles. “Foreign” small RNAs derived from bacteria, plants and parasites have also been detected in mammalian body fluids, sparking interest in whe...
ORGANISM(S): Litomosoides sigmodontis 
2014-11-26 | E-GEOD-60021 | biostudies-arrayexpress
TranscriptomicsExosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system [Heligmosomoides polygyrus]
In mammalian systems, extracellular small RNAs can operate in a paracrine manner to communicate information between cells, relying on transport within vesicles. “Foreign” small RNAs derived from bacteria, plants and parasites have also been detected in mammalian body fluids, sparking interest in whe...
ORGANISM(S): Heligmosomoides polygyrus 
2014-11-25 | E-GEOD-55978 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of the effects of a parasitic nematode's secreted exosomes on mammalian cells.
We show that a gastrointestinal nematode that infects mice, Heligmosomoides polygyrus, secretes vesicles packaged with specific microRNAs (miRNAs) and Y RNAs as well as a nematode-specific Argonaute protein. The vesicles are of intestinal origin and are enriched for homologs of mammalian proteins fo...
ORGANISM(S): Mus musculus 
2014-12-24 | E-GEOD-55941 | biostudies-arrayexpress
Sort   by:  
 Page size