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TranscriptomicsExpression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dep...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-19796 | biostudies-arrayexpress
TranscriptomicsExpression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP)
The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through tra...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-32929 | biostudies-arrayexpress
TranscriptomicsCritical role of SOX17 in the hematopoietic development from human embryonic stem cells
Human embryonic stem cells (hESCs) are a powerful tool for modeling regenerative therapy. To search for the genes that promote hematopoietic development from human pluripotent stem cell, we overexpressed a list of hematopoietic regulator genes in human pluripotent stem cell-derived CD34+CD43- endoth...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-38156 | biostudies-arrayexpress
TranscriptomicsHoxB4 in hematopoietic stem cells
Ectopic expression of homeodomain transcription factor HoxB4 in mouse ES cells enhances in vitro development of hematopoietic stem cells (HSCs). Mouse ES cells were differentiated for 6 days in EBs, then c-Kit+CD41+ hematopoietic precursor cells were isolated, plated onto OP9 cells, and transduced w...
ORGANISM(S): Mus musculus 
2011-05-23 | E-GEOD-26653 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip data from human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) overexpressing 3xFLAG-Sox17-ERT
Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells enhances expansion of hemogenic endothelium-like cells. Human ES cells were differentiated for 6 days in EBs, then CD34+CD43-CD45- endothelial cells were isolated, plated onto OP9 cells, and transduced with the ...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-37528 | biostudies-arrayexpress
TranscriptomicsExpression data of human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) expanded upon overexpression of Sox17
Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells and hematopoietic cells enhances expansion of hemogenic endothelium-like cells. Human ES cells were differentiated for 6 days, 8 days or 12 days in EBs, then CD34+CD43-CD45- endothelial cells, CD34+CD43+CD45- pr...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-37348 | biostudies-arrayexpress
TranscriptomicsExpression data from Tet2-hypomorph (knockdown) and/or Ezh2-null Lineage-Sca-1+c-Kit+ (LSK) cells and granulocyte-macrophage progenitors (GMPs)
PcG proteins form the polycomb repressive complexes (PRC) 1 and 2, functioning as transcriptional repressors through histone modifications. They have been implicated in the maintenance of self-renewing somatic and cancer stem cells. PcG genes have been characterized as tumor suppressor genes as exem...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-42666 | biostudies-arrayexpress
TranscriptomicsExpression data from Ezh2-null leukemic cells
The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through tra...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-33808 | biostudies-arrayexpress
TranscriptomicsExpression data from Bmi1-null common myeloid progenitor (CMP)
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dep...
ORGANISM(S): Mus musculus 
2012-02-08 | E-GEOD-31086 | biostudies-arrayexpress
TranscriptomicsExpression data from Fus/TLS-null KSL hematopoietic stem/progenitor cells
Fus is the gene for a member of the FET family of RNA-binding proteins often involved in chromosomal translocations to generate oncogenic fusion genes in human cancers. Fus participates in multiple cellular functions, including RNA processing and transport, transcriptional regulation, and genome int...
ORGANISM(S): Mus musculus 
2009-11-02 | E-GEOD-18853 | biostudies-arrayexpress
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