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MetabolomicsUntargeted metabolomics analyses and contaminant chemistry of Dreissenid mussels at the Maumee River Area of Concern in the Great Lakes

Bivalves serve as an ideal ecological indicator; hence, their use by the NOAA Mussel Watch Program to monitor environmental health. This study aimed to expand the baseline knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the ...

2024-06-03 | MTBLS6311 | MetaboLights
GenomicsDNA IP for 5hmC modified CpGs in the liver of control mice and a Tet1 -/- mouse liver [hmeDIP-seq]
Through the analysis of mouse liver tumours promoted by distinct routes (DEN exposure alone, DEN exposure plus non-genotoxic insult with phenobarbital and non-alcoholic fatty liver disease); we report that the cancer associated hyper-methylated CGI events in mice are also predicated by silent promot...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-77730 | biostudies-arrayexpress
TranscriptomicsPancreas-specific Sirt1-deficiency in mice compromises beta-cell function without development of hyperglycemia
Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. The effects on islet cells and blood glucose levels when Sirt1 is deleted specifically in the pancreas are still unclear.This study examined islet glucose respons...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-67239 | biostudies-arrayexpress
TranscriptomicsAndrogen dependent gene expression profiling of the urogenital sinus
Cancer cells differentiate along specific lineages that largely determine their clinical and biologic behavior. Distinct cancer phenotypes from different cells and organs likely result from unique gene expression repertoires established during lineage commitment in the embryo and maintained after ma...
ORGANISM(S): Mus musculus 
2008-12-03 | E-GEOD-12077 | biostudies-arrayexpress
TranscriptomicsIsolation and next generation sequencing of epididymal extracellular vesicles reveals segmental patterns of miRNA expression and a potential mechanism for modification of the sperm epigenome.
Interest in the sperm epigenome continues to grow in view of the realization that it is vulnerable to dynamic modifications arising from a variety of paternal environment exposures and that this legacy can serve as an important determinant of intergenerational inheritance. It has been postulated tha...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-79500 | biostudies-arrayexpress
TranscriptomicsHuman cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 1A)
Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an ...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-37664 | biostudies-arrayexpress
TranscriptomicsHuman cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2C)
Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an ...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-37826 | biostudies-arrayexpress
TranscriptomicsHuman cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2A)
Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an ...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-37670 | biostudies-arrayexpress
TranscriptomicsCircular RNAs are enriched in anucleate platelets and are a signature of transcriptome degradation
In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly quantified on a transcriptome-wide level. As circular RNAs (circRNAs) are resistant to degradation by exonucleases, their ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-69192 | biostudies-arrayexpress
TranscriptomicsArray analysis of wound induced hair neogenesis (early stage)
Mice were wounded and skin samples of the scar collected on the day of wound closure. We compared Mixed mice (B6/FVB/SJL), a strain of high regeneration, versus C57bl mice, a strain of low regeneration. Whole skin biopsies of wound scars were submitted for Affymetrix Exon arrays. 4 mice each of ...
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-50418 | biostudies-arrayexpress
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