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TranscriptomicsA role for Multidrug Resistance Protein 4 (MRP4; ABCC4) in human Dendritic Cell migration.
The capacity of dendritic cells (DC) to migrate from peripheral organs to lymph nodes (LN) is an important event in the initiation of a T cell-mediated immune response. Previously it was shown that the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp; ABCB1) and the 2 multidrug resistanc...
ORGANISM(S): Homo sapiens 
2008-07-12 | E-GEOD-12089 | biostudies-arrayexpress
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
ProteomicsConfirmation of the subunit composition of Rhodobacter sphaeroides cytochrome bc1 complex isolated in styrene maleic acid nanodiscs.
The purple α-proteobacterium Rhodobacter sphaeroides is a long-established model organism owing to its ability to switch between aerobic, anaerobic and phototrophic metabolism. This organism is also of great interest because of its phylogenetic relationship with the bacterial progenitor of the mitoc...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2023-03-14 | PXD039340 | Pride
Subunit iv Lc-ms/ms Rhodobacter sphaeroides Purple bacteria Cytochrome bc1 complex Photosynthesis 
TranscriptomicsTranscription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration of lymphatic vessel endothelium.
The exit of antigen-presenting cells (APC) and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels is however unknown. Here we show ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-6257 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of mock-injected and AP20187-treated mice of wildtype and Atf4-/- genotype
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2α (eIF2α)-specific phosphatase, GADD34, was used to selectively comp...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11116 | biostudies-arrayexpress
UnknownMutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Not available
S-EPMC6485456 | biostudies-literature
UnknownRates of Primary Care and Integrated Mental Health Telemedicine Visits Between Rural and Urban Veterans Affairs Beneficiaries Before and After the Onset of the COVID-19 Pandemic.
Not available
S-EPMC9993180 | biostudies-literature
UnknownParadoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection.
Not available
S-EPMC9200151 | biostudies-literature
UnknownWhole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
Not available
S-EPMC9395431 | biostudies-literature
ProteomicsIntegrated Dissection of Cysteine Oxidative Modification Proteome During Cardiac Hypertrophy
Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development. However, integrated dissection of multiple types of cysteine oxidation proteome in cardiac hypertrophy is currently missing. Here we developed a novel discovery platform encompassing ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-29 | PXD010336 | Pride
Mouse Cardiac hypertrophy Heart Biotin switch Dimethyl labeling Cysteine oxidation Reversible cysteine oxidation Cysteine sulfinylation Cysteine sulfonylation Quantitative proteomics 
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