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ProteomicsImmunometabolism in resolving atherosclerosis guides the development of nanometabolite therapy
A 6-month in vivo study will be carried out at Case Western Reserve University (CWRU) using an ApoE-/- mouse model of atherosclerosis (obtained from The Jackson Laboratory), which will be treated as follows: Control: Mice fed a chow diet (control) (n=12) Progression: Mice fed a high-fat diet with ch...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD041137 | Pride
Organoids Stable isotope metabolomics Mouse Aorta 
ProteomicsUnderstanding early AutoAb signatures in Pituitary Adenomas using CDI HuProt™ (Human Proteome Microarray)
CDI HuProt™ (Human Proteome Microarray), was used to study Pituitary Adenomas PAs (Acromegaly, Cushing's and NFPA) using serum samples, from around 14 individuals (4 Healthy control, 4 Acromegaly, 3 Cushing’s and 3 NFPAs patient samples) were used study their autoantibody profiles. Patient serum sam...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-11947 | biostudies-arrayexpress
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq]
Two separate pools of three Flox or two Lrh1t-/- pancreas RNA preparations was subjected to the Illumina RNA-seq protocol. Examination of mRNA levels in induced Lrh1 pancreas knockout and wild-type mice.
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-34030 | biostudies-arrayexpress
GenomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [ChIP-Seq]
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in the exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mit...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34295 | biostudies-arrayexpress
UnknownMutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Not available
S-EPMC6485456 | biostudies-literature
ProteomicsComplement C3 deposition on nucleic acids is characteristic of immune complex initiated classical pathway overdrive in lupus erythematosus
Systemic lupus erythematosus is progressive, immune complex-mediated autoimmune disease targeting numerous organs. A central feature of the disease is the development of antibodies against nuclear components, including DNA. Antibodies against double-stranded DNA are so characteristic of this disease...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-26768 | biostudies-arrayexpress
GenomicsNHLBI Coronary Artery Risk Development in Young Adults (CARDIA) Candidate Gene Association Resource (CARe)

The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining the development and determinants of clinical and subclinical cardiovascular disease and its risk factors. It began in 1985 with a group of 5115 black and white men and women aged 18-30 years. The participan...

phs000285.v2.p2 | EGA
UnknownHIV-1 genetic diversity and demographic characteristics in Bulgaria.
Not available
S-EPMC6538145 | biostudies-literature
UnknownNo interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Not available
S-EPMC3331745 | biostudies-literature
Genomicsena-DATASET-UAMS-17-03-2019-03:57:35:391-32 - samples
Series of 56 paired presentation, relapse and control samples from newly diagnosed, uniformly treated myeloma patients. Deep of treatment response and maintenance allocation (active observation or lenaldiomide) was determined for all. All samples underwent whole exome sequencing with additional bait...
EGAD00001004846 | EGA
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