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MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsWhole transcriptome profiling of 79 patient derived xenograft (PDX) models
RNA-Seq and a species-specific mapping strategy were used to profile the human and mouse transcriptomes of tumour samples taken from 79 PDX models representing multiple cancer types (19 x breast, 37 x lung, 8 x colorectal, 7 x ovarian, 3 x endometrial, 2 x pancreatic, 2 x ampullary, 1 x leukaemia).
ORGANISM(S): Mus musculus 
2016-03-01 | E-MTAB-3980 | biostudies-arrayexpress
ProteomicsGenetic determinants of genomic stability identified by comprehensive in vivo analyses of micronucleus formation
Genomic instability due to defective DNA damage response or arising from mitotic chromosomal imbalance can lead to sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of genomic instability associated diseases and ageing, the catalogue of gen...
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD030499 | Pride
Ms3 Human Tmt 
ProteomicsProteomic analysis of Dscc1 knockout mouse cells
In this project we aimed to explore the effect of Dscc1 gene loss on the proteome. Embyros from wildtype and aged matched Dssc1 null embryos were profiled.
ORGANISM(S): Mus musculus (Mouse) 
2023-11-17 | PXD034902 | Pride
Knock out Ms/ms Dscc1 Mouse 
Unknown14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.
Not available
S-EPMC5052641 | biostudies-literature
UnknownEmergency medical services intervals and survival in trauma: assessment of the "golden hour" in a North American prospective cohort.
Not available
S-EPMC3008652 | biostudies-literature
UnknownModification of diet, exercise and lifestyle (MODEL) study: a randomised controlled trial protocol.
Not available
S-EPMC7661361 | biostudies-literature
GenomicWhole Genome Association Study of Visceral Adiposity in the HABC Study

The Health Aging and Body Composition (Health ABC) Study is a NIA-sponsored cohort study of the factors that contribute to incident disability and the decline in function of healthier older persons, with a particular emphasis on changes in body composition in old age. Between 4/15/97 and 6...

phs000169 | dbGaP
ProteomicsRNF5 interactome
Cells expressing Flag-tagged RNF5 or empty vector were incubated with the proteasome inhibitor MG132 to block protein degradation. Cell lysates were then prepared and immunoprecipitationed with anti-Flag antibody were performed, and eluates were digested with trypsin and analyzed on a Q Exactive.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-25 | MSV000083160 | MassIVE
UnknownPI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
Not available
S-EPMC10940093 | biostudies-literature
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