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Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
Through the analysis of mouse liver tumours promoted by distinct routes (DEN exposure alone, DEN exposure plus non-genotoxic insult with phenobarbital and non-alcoholic fatty liver disease); we report that the cancer associated hyper-methylated CGI events in mice are also predicated by silent promot...
ORGANISM(S): Mus musculus 
nccRCC tumor/normal genotypes
nccRCC Whole Exome sequencing data (consented samples only)
nccRCC RNA-Seq data of consented samples
Targeted exome sequencing of 375 genes
Study of non-clear cell renal cell carcinoma
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