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TranscriptomicsEctopic expression of AP4 in human colorectal cancer cells DLD-1 for different times
To characterize the transcriptome of the transcription factor AP4 DLD-1 cells were infected with AP4 coding viruses for different periods of time. Adenovirus amplification and purification was performed as previously described (He et al., 1998). The minimal amount of virus needed to reach more than ...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-46578 | biostudies-arrayexpress
GenomicsChIP-seq of AP4 binding in human colorectal cancer cells DLD-1.
In order to comprehensively identify genes directly regulated by AP4, a genome-wide chromatin-immunoprecipitation analysis (ChIP) followed by next generation sequencing (ChIP-seq) was performed after activation of a conditional AP4 allele in DLD-1 cells. One DLD-1 Sample was sequenced.
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-46935 | biostudies-arrayexpress
TranscriptomicsRNA-seq of intestinal cancer GEMMs
Intestinal tumours from genetically engeenierd mouse modesl (GEMMs), of various gentopyes, were isolated at endpoint and RNA was isolated. In an additional experiment, epithelial tumour organoids were isolated at end point and grown in vitro. These organoids were harvested 72 hours after seeding and...
ORGANISM(S): Mus musculus 
2019-09-16 | E-MTAB-6363 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of genetically engineered mouse tumors using SOCRATES
This dataset contains single-cell RNA sequencing data from murine colorectal tumors engineered using the SOCRATES platform, a CRISPR-based multiplex genome engineering system. Tumors were initiated in genetically engineered mouse models via lentiviral delivery of pooled sgRNAs targeting key driver g...
ORGANISM(S): Mus musculus 
2026-05-01 | E-MTAB-15044 | biostudies-arrayexpress
TranscriptomicsTimecourse analysis of human colorectal cancer organoids under FOLFIRI chemotherapy
Two human colorectal cancer organoids derived from liver metastasis of the same patient were grown for seven days, then treated with FOLFIRI chemotherapy in vitro and sampled at different timepoints for single-cell RNA-sequencing. Time points include 0 h, 12 h, 24 h, 48 h, 72 h and 120 h on-treatmen...
ORGANISM(S): Homo sapiens 
2026-04-01 | E-MTAB-16836 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-sequencing of murine colorectal cancer tumors
Murine adenocarcinoma models VAKPS (Villin1-CreER Apc-fl/+ Kras-G12D/+ Trp5-3fl/fl Smad4-fl/fl) and VKPN (Villin1-CreER Kras-G12D/+ Trp53-fl/fl Rosa26-N1icd/+) were injected into mice to grow into subcutaneous tumors. Tumors were profiled through multiplexed single-cell RNA-sequencing.
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16835 | biostudies-arrayexpress
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