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TranscriptomicsPatterns of micro RNA expression characterize stages of human B-cell differentiation
Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B-cells constitute the majority of leukemias and lymphomas. These malignancies often maintain the characteristics of the normal B-cells that they are derived from,...
ORGANISM(S): Homo sapiens 
2009-03-16 | E-GEOD-15250 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B cells Identifies Hundreds of Novel MicroRNAs: microarray analysis
A role for microRNAs has been recognized in nearly every biological system examined thus far. A complete delineation of their role must be preceded by the identification of all microRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through...
ORGANISM(S): Homo sapiens 
2010-08-26 | E-GEOD-22895 | biostudies-arrayexpress
TranscriptomicsThe Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells
Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes as well as the regulation of host genes. Given the important role of miRNAs in regulating fund...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-36926 | biostudies-arrayexpress
TranscriptomicsThe genetic landscape of mutations in Burkitt lymphoma
Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequen...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-48435 | biostudies-arrayexpress
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