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MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
ProteomicsBiomolecular condensation orchestrates clathrin-mediated endocytosis in plants
Clathrin-mediated endocytosis is an essential cellular internalisation pathway involving the dynamic assembly of clathrin and accessory proteins to form membrane-bound vesicles. The evolutionarily ancient TSET/TPLATE complex (TPC) plays an essential, but not well-defined role in endocytosis in plant...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-12-07 | PXD045068 | Pride
Ap-ms Arabidopsis Clathrin-mediated endocytosis Tplate complex Ateh1 
UnknownGenome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain.
Not available
S-EPMC4651095 | biostudies-literature
UnknownMutations improving production and secretion of extracellular lipase by Burkholderia glumae PG1.
Not available
S-EPMC4717159 | biostudies-literature
ProteomicsMolecular architecture of the endocytic TPLATE complex – part1 TAP/BS3 cross-linking dataset
Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-03-04 | PXD023022 | Pride
Tset Arabidopsis Structure Tplate complex Bs3 cross-linking 
ProteomicsFASN-dependent de novo lipogenesis is required for brain development
Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. H...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD026110 | Pride
Fasn Human Mouse Lipogenesis Brain development Brain organoids 
TranscriptomicsVariation in homeodomain DNA-binding revealed by high-resolution analysis of sequence preferences
Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the majority (168) of mouse homeodomains to all possible 8-base sequences, re...
ORGANISM(S): Mus musculus 
2010-06-26 | E-GEOD-11239 | biostudies-arrayexpress
ProteomicsThe endocytic TPLATE complex internalizes ubiquitinated plasma membrane cargo
Endocytosis controls the perception of stimuli by modulating protein abundance at the plasma membrane. In plants, clathrin-mediated endocytosis is the most prominent internalization pathway and relies on two multimeric adaptor complexes, the AP-2 and the TPLATE complex (TPC). Ubiquitination is a wel...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-03-11 | PXD035444 | Pride
Ap-ms Arabidopsis Tplate complex Endocytosis 
ProteomicsMolecular architecture of the endocytic TPLATE complex – part2 IP-MS dataset
Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-03-04 | PXD023051 | Pride
Tset Arabidopsis Structure Ip-ms Tplate complex 
TranscriptomicsMethylome-wide analysis of chronic HIV infected patients and healthy controls
Current therapy has turned HIV infection into a chronic condition. Clinically, some patients suffer prematurely from ailments associated with advanced age; however, the relationship between HIV and aging is unclear. Here we have collected a large cohort of HAART treated HIV+ subjects with both recen...
ORGANISM(S): Homo sapiens 
2016-04-03 | E-GEOD-67705 | biostudies-arrayexpress
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