Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human FoxP3+CD4+CD25+high regulatory T cells (Tregs) isolated from recent-onset type 1 diabetes mellitus (T1D) patients and controls
Naturally occurring FoxP3+CD4+CD25+high regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing auto-reactive CD4+CD25- T cell activity. Although Tregs from T1D subjects are functionally deficient, there is little knowledge of the molecular mechanisms that orchestrate th...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10586 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.
Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, a...
ORGANISM(S): Homo sapiens 
2010-09-16 | E-GEOD-24147 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat identifies of a serum induced transcriptional signature associated with type 1 diabetes
Human type 1 diabetes (T1D) arises through autoimmunity towards the insulin-producing pancreatic β cells and is modeled by the BioBreeding (BB) rat. Factors associated with islet autoimmunity are dilute and difficult to directly measure in the periphery. Therefore, we previously utilized microarray...
ORGANISM(S): Rattus norvegicus 
2009-12-25 | E-GEOD-19537 | biostudies-arrayexpress
TranscriptomicsThree-dimensional proximity mapping of the DRGFP DNA double-strand break site in U2OS cells
We mapped the DNA sequences located in physical proximity to an I-SceI endonuclease-dependent DNA double-strand break (DSB) site to be able to study the impact of DSBs on the break-associated chromatin micro-environment. The I-SceI DSB site is part of a DRGFP transgene that serves as a reporter for ...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-58563 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human unstimulated regulatory T cells (Tregs) and naïve CD4+ T cells
Human regulatory T cells (TR) cells have potential for the treatment of immune mediated diseases, such as graft versus host disease, but the anergic phenotype of these cells makes them difficult to expand in vitro. We have examined the requirements for growth and cytokine expression from highly pur...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22045 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pancreatic islets in BioBreeding rats
Like humans, the NOD mouse and other diabetes susceptible rat strains, T1D in BB rats is dependent on the major histocompatibility complex (MHC, insulin dependent diabetes mellitus locus 1, Iddm1) located on chromosome 20. In rats this is the HLA-DQB1 homologue RT1-B, specifically the RT1u haplotype...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20214 | biostudies-arrayexpress
Sort   by:  
 Page size