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GenomicsThe ChIP-Sequence data of STAT92E in Drosophila adult intestines
JAK/STAT pathway plays important roles in controlling Drosophila intestinal homeostasis and regulating the ISC proliferation and differentiation. However,the downstream targets of its transcription factor-STAT92E remain largely unknown.To further identify the regualtory mechanisms of the JAK/STAT pa...
ORGANISM(S): Drosophila melanogaster 
2015-05-12 | E-GEOD-67346 | biostudies-arrayexpress
TranscriptomicsExpression profiling in the Drosophila eye reveals unexpected repression of Notch signaling by the JAK/STAT pathway
Although the JAK/STAT pathway regulates numerous processes in vertebrates and invertebrates through modulating transcription, its functionally-relevant transcriptional targets remain largely unknown. With one jak and one stat (stat92E), Drosophila provides a powerful system for finding new JAK/STAT ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-GEOD-15868 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [MPN patients]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54644 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54645 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Kc167 cell line
The consitutive activation of the JAK/STAT signalling cascade is reponsible for the majority of meyoproliferative disorders in humans, a disease that is also conserved in Drosophila. A gain-of-function mutation in the Drosophila JAK kinase leads to blood cell (haemocyte) overproliferation which even...
ORGANISM(S): Drosophila melanogaster 
2009-09-12 | E-GEOD-15584 | biostudies-arrayexpress
ProteomicsIntegration of JAK/STAT receptor-ligand trafficking, signalling and gene expression in Drosophila melanogaster cells
The JAK/STAT pathway is an essential signalling cascade required for multiple processes during both development and for adult homeostasis. A key question in understanding this pathway is how it is regulated in different cell contexts. Here we have examined how endocytic processing contributes to sig...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-09-29 | PXD020719 | Pride
Endocytosis Phosphorylation Drosophila Jak/stat signalling Lc-ms/ms 
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54646 | biostudies-arrayexpress
GenomicsEfficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile as well as a high rate of induction failure. Frequent mutations in cytokine receptor and JAK/STAT signaling pathways led us to hypoth...
EGAS00001001146 | EGA
TranscriptomicsJAK/STAT coordinates cell proliferation during disc regeneration with Dilp8-mediated developmental delay in Drosophila melanogaster
Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner, involving local cell proliferation at the wound site. Following disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation and repatterning of t...
ORGANISM(S): Drosophila melanogaster 
2015-04-10 | E-GEOD-54868 | biostudies-arrayexpress
GenomicsJAK and STAT alterations in CD30 positive LPD
The group of cutaneous CD30-positive lymphoproliferative disorders (LPD) comprises two different entities, namely lymphomatoid papulosis (LyP) and cutaneous anaplastic large T-cell lymphoma (cALCL). LyP constitutes a benign lymphoproliferation with spontaneously regressing papules, whereas cALCL pre...
EGAS00001004181 | EGA
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