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GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ChIP-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates. As a proto-oncogene, targeted MYCN overexpression i...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80151 | biostudies-arrayexpress
TranscriptomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ATAC-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates1,2. As a proto-oncogene, targeted MYCN overexpressio...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80152 | biostudies-arrayexpress
ProteomicsMitochondrial content normalization using mass spectrometry allows quantitative evaluation of intrinsic bioenergetic efficiency and the underlying proteome across mouse organs.
To separate global changes to metabolism from intrinsic mitochondrial remodeling, investigators commonly use isolated mitochondrial preparations obtained through differential centrifugation. This simple process has been reliably implemented in a variety of tissues to produce intact, functional mitoc...
ORGANISM(S): Mus Musculus (mouse) 
2021-07-09 | PXD020280 | JPOST Repository
GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80154 | biostudies-arrayexpress
UnknownReproducibility of Ocular Surface Staining in the Assessment of Sjogren Syndrome-Related Keratoconjunctivitis Sicca: Implications on Disease Classification.
Not available
S-EPMC6710016 | biostudies-literature
ProteomicsMitochondrial proteome of human leuekmia.
Proteome characterization of isolated mitochondria samples prepared from three commonly used acute leukemia cell lines (HL-60, KG-1, MV-4-11). Data were compared to isolated mitochondria prepared from peripheral blood mononuclear cells (PBMC), isolated from healthy human subjects.
ORGANISM(S): Homo Sapiens (human) 
2020-08-04 | PXD020715 | JPOST Repository
TranscriptomicsMicroRNA-520c-3p targets eIF4GII and acts as a tumor suppressor in diffuse large B cell lymphoma
Deregulation of the translational machinery is emerging as a critical contributor to lymphomagenesis. Various miRNA alterations have been identified in lymphoma, but their role in disrupting the cap-dependent translation regulation complex remains poorly understood. Here, we demonstrate the translat...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-40489 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Analysis of Rat Brain Following Exposure to the Organophosphonate Anticholinesterase Sarin
Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasures to nerve agent intoxication increase survival if administered within a short period of time following exposure but...
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-GEOD-28435 | biostudies-arrayexpress
ProteomicsBlue native gel electrophoresis of Syntrophus aciditrophicus proteome
Blue native gel electrophoresis of Syntrophus aciditrophicus proteome
ORGANISM(S): Syntrophus Aciditrophicus Sb 
2019-04-29 | PXD011101 | JPOST Repository
ProteomicsAnalyze key proteins in Syntrophus aciditrophicus
Pure cultures of S. aciditrophicus grown in 250 ml of 20 mM crotonate medium in 500-ml Schott bottles were used for proteomic analysis after 2-dimensional (2-D) PAGE.
ORGANISM(S): Syntrophus Aciditrophicus Sb 
2019-04-29 | PXD011100 | JPOST Repository
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