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TranscriptomicsLoss of Hic1 tumor suppressor potentiates Tlr2/NF-kB signaling and promotes tissue damage-associated tumorigenesis in the colon.
Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene frequently inactivated by DNA methylation in many types of solid tumors. The gene encodes a sequence-specific transcriptional repressor controlling expression of several genes involved in the cycle or stress control. In...
ORGANISM(S): Mus musculus 
2016-02-01 | E-MTAB-3486 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in colon organoids isolated from germ-free, E.coli strains Nissle 1917 and O6K13 monoassociated, and conventionally reared mice
Commensal microbiota contribute to gut homeostasis and influence gene expression. Intestinal organoid culture closely represent intestinal epithelium and retain intestinal stem cells and dynamic recovery capabilities as well as all major cell types of the intestinal epithelium. We established organo...
ORGANISM(S): Mus musculus 
2019-09-13 | E-MTAB-7723 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Defa6+ cells isolated from Apc-deficient colon tumor using single-cell RNA-Seq
Aberrant activation of the canonical Wnt pathway underlines the development and growth of intestinal tumors. The Apc-min (multiple intestinal neoplasia) mouse strain carries a single nucleotide mutation in one allele of the Apc tumor suppressor gene. Random deactivation of the second allele occurs d...
ORGANISM(S): Mus musculus 
2025-04-01 | E-MTAB-13752 | biostudies-arrayexpress
TranscriptomicsSingle cell expression analysis of Defa6+ cells possessing either wild-type Tcf4 or homozygous loss of the Tcf4 protein isolated from mouse small intestinal epithelium
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a crucial regulator of Paneth cell function in s...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-14489 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-Seq expression profiling of RFP-positive cells isolated from Ki67-RFP/Tcf7l2/Villin-CreERT2 mouse small intestinal epithelium 7 days after tamoxifen administration
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a key regulator of Paneth cell function in small...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-13731 | biostudies-arrayexpress
TranscriptomicsSingle cell expression profiling of murine subventricular zone in adult brain three days after focal celebral ischemia
Ischemic stroke is a serious medical condition that leads to the onset of neurological symptoms such as loss of motor and cognitive functions. Focal cerebral ischemia (FCI) occurs due to the interrupted blood supply to the site of injury, resulting in the demise of brain cells. The subventricular zo...
ORGANISM(S): Mus musculus 
2021-01-01 | E-MTAB-9935 | biostudies-arrayexpress
TranscriptomicsSingle cell expression profiling of NG2 cell lineage upon constitutive activation of Wnt/β-catenin signaling in adult mice cortex three days after focal celebral ischemia
Ischemic stroke is a severe medical condition that leads to neurological impairments, including the loss of sensory, motor, and cognitive functions. Focal cerebral ischemia (FCI) occurs when blood supply to a specific brain region is interrupted, resulting in cell death. Cells expressing neural-glia...
ORGANISM(S): Mus musculus 
2026-08-05 | E-MTAB-14958 | biostudies-arrayexpress
TranscriptomicsSingle cell expression profiling of NG2 cell lineage upon inhibition of Wnt signaling in adult mice cortex three days after focal celebral ischemia
Ischemic stroke is a severe medical condition that leads to neurological impairments, including the loss of sensory, motor, and cognitive functions. Focal cerebral ischemia (FCI) occurs when blood supply to a specific brain region is interrupted, resulting in cell death. Cells expressing neural-glia...
ORGANISM(S): Mus musculus 
2026-08-05 | E-MTAB-14905 | biostudies-arrayexpress
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