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ProteomicsMolecular Basis and Cellular Effects of Janus-Class–Driven Cytoplasmic PYK2 Coacervates
Kinase activity is increasingly associated with biomolecular phase separation. Focal adhesion kinase (FAK) forms membrane-associated condensates with paxillin to promote adhesion. Here we show that its paralogue, proline-rich tyrosine kinase 2 (PYK2), undergoes phase separation via a distinct mechan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-11 | PXD072123 | Pride
Focal adhesion Esm2 Cancer Kinase Phase separation Janus class 
GenomicsJanus kinase 1 plays a critical role in mammary cancer progression
Janus kinase 1 plays a critical role in mammary cancer progression
PRJNA495488 | ENA
TranscriptomicsClass prediction models of thrombocytosis using genetic biomarkers
Using custom spotted oligonucelotide platelet-focused arrays, platelet samples were compared. 48 health controls, 23 reactive thrombocytosis (RT) and 24 essential thrombocythemia (ET) samples were compared. An 11-biomarker gene subset was identified that discriminated among the three cohorts with 86...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-12295 | biostudies-arrayexpress
TranscriptomicsJanus kinase 1 plays a critical role in mammary cancer progression
Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a novel breast cancer model that conditionally lacks the Janus kinase 1, we show here that JAK1 is essential for IL-6 class inflammatory cytokine signaling ...
ORGANISM(S): Mus musculus 
2019-03-27 | GSE121064 | GEO
GenomicsJanus kinase-Inhibition modulates hepatitis E virus infection
Janus kinase-Inhibition modulates hepatitis E virus infection
PRJNA932725 | ENA
GenomicsStretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60482 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
UnknownAn Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity.
Not available
S-EPMC10755735 | biostudies-literature
UnknownBioinspired Polymeric High Aspect Ratio Particles with Asymmetric Janus Functionalities.
Not available
S-EPMC8115014 | biostudies-literature
UnknownTargeting the Janus Kinase Family in Autoimmune Skin Diseases.
Not available
S-EPMC6794457 | biostudies-literature
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