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Identification of potential tumor suppressor genes using the GINI strategy in Mantle Cell Lymphoma cell lines Experiment Overall Design: Inhibition of the NMD pathway was performed in Mantle Cell Lymphoma cell lines according to a modified protocol previously described (Noensie EN et al Nat Biotechn...
ORGANISM(S): Homo sapiens 
Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the gen...
ORGANISM(S): Homo sapiens 
Gene expression analyis of primary MCL including IGHV mutated and unmutated cases Gene set analysis was perfomed in MCL samples, comparing IGHV mutated cases vs. IGHV unmutated cases In total 38 MCL samples were processed with the HU133plus 2.0 microarray. Twenty four cases had a IGHV mutations and...
ORGANISM(S): Homo sapiens 
The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL), but its functional role in malignant B-cells is unknown. To identify target genes transcriptionally regulated by SOX11 in malignant lymphoid cells, we have used Gene Expressi...
ORGANISM(S): Homo sapiens 
Genome wide DNA methylation profiling of primary MCL. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Bisulphite converted DNA from the 132 samples were hybridised to the Illumina Infinium 27k Human Methylati...
ORGANISM(S): Homo sapiens 
MCL cell lines were treated with aza and aza in combination with TSA. MCL cell lines were treated with aza and aza in combination with TSA. Gene expression following drug treatment was compared with untreated cells.
ORGANISM(S): Homo sapiens 
CLL Expression Array
The Chronic Lymphocytic Leukemia (CLL) Genome Project aims to identify genetic alterations involved in the development and progression of the CLL, which are still unknown, with the objective of generating a comprehensive catalogue of genetic alterations in 500 independent tumours. The CLL Genome Pro...
Deep RNA sequencing in CLL
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