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TranscriptomicsDissecting the signalling pathways underlying cellular senescence
Cellular senescence is a program of irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress. The underlying signalling pathways, potentially of major clinicopathological rele...
ORGANISM(S): Homo sapiens 
2011-01-21 | E-GEOD-24810 | biostudies-arrayexpress
TranscriptomicsHMF3A_with_3Dwt
HMF3A cells, created from adult human mammary fibroblasts by immortalisation with a thermolabile SV40 large T antigen and the catalytic sub-unit of human telomerase, undergo co-ordinated induction of cellular senescence upon inactivation of T antigen. HMF3A cells cease proliferating by 4 days at 39Â...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-688 | biostudies-arrayexpress
TranscriptomicsPrim_Fibs
To determine changes in gene expression in primary fibroblasts undergoing replicative senescence, a direct comparison between early passage proliferating cells and senescent cells was performed. Frozen stocks of the primary fibroblasts (HMF3) from which the lines HMF3A and HMF3Dwt were derived (O'Ha...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-687 | biostudies-arrayexpress
TranscriptomicsHMF3A_RNAi
HMF3A cells, created from adult human mammary fibroblasts by immortalisation with a thermolabile SV40 large T antigen and the catalytic sub-unit of human telomerase, undergo co-ordinated induction of cellular senescence upon inactivation of T antigen. The pSUPER-retro vector system (Brummelkamp, 200...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-690 | biostudies-arrayexpress
TranscriptomicsA novel unusual chromosome 11 abnormality: a homozygous somatic deletion of the entire WT1 gene within a heterozygous 11p13 deletion and UPD limited to 11p15 in a Wilms tumor and establishment of an immortalized cell line
We describe a stromal predominant Wilms tumor with a complex, tumor specific chromosome 11 aberration: a homozygous deletion of the entire WT1 gene within a heterozygous 11p13 deletion and an additional region of uniparental disomy (UPD) limited to 11p15.5-p15.2 including the IGF2 gene. The tumor ca...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-71265 | biostudies-arrayexpress
UnknownTranscriptional networks and cellular senescence in human mammary fibroblasts.
Not available
S-EPMC545924 | biostudies-literature
UnknownTumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma.
Not available
S-EPMC10110583 | biostudies-literature
UnknownA global phylogeny of butterflies reveals their evolutionary history, ancestral hosts and biogeographic origins.
Not available
S-EPMC10250192 | biostudies-literature
UnknownElective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries.
Not available
S-EPMC9621702 | biostudies-literature
UnknownElevated pulse pressure and cardiovascular risk associated in Spanish population attended in primary care: IBERICAN study.
Not available
S-EPMC10203900 | biostudies-literature
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