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TranscriptomicsCell-cycle regulation of cohesin stability along fission yeast chromosomes
Sister chromatid cohesion is mediated by cohesin but the process of cohesion establishment during S phase is still enigmatic. Recent data indicate that in mammalian cells, cohesin binding to chromatin is dynamic in G1 but becomes stabilized during S phase. Whether the regulation of chromosomal cohes...
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-30 | E-GEOD-8450 | biostudies-arrayexpress
TranscriptomicsAnalysis of cohesin-dependent gene regulation in fission yeast
In addition to its well-know function in chromosome segregation, increasing evidence implicates cohesin in the control of gene expression. It has been previously reported that inactivation of the cohesin loader Mis4 in G1-arrested cells leads to the dissociation of cohesin from chromatin. We exploit...
ORGANISM(S): Schizosaccharomyces pombe 
2010-08-12 | E-GEOD-23602 | biostudies-arrayexpress
TranscriptomicsIsocitrate dehydrogenase 1 mutations prime the all-trans-retinoic acid myeloid differentiation pathway in acute myeloid leukemia HL-60 cells
Human acute myeloid leukemia HL60 cells were transduced with IDH1-WT or IDH1-R132H, and corresponding sub-clones were generated by FACS. In a first series of experiments, cells expressing wt and mutant IDH1were treated with either 1µM all-trans retinoic acid (ATRA) or with vehicle (DMSO) for 24 hrs...
ORGANISM(S): Homo sapiens 
2017-03-01 | E-MTAB-4327 | biostudies-arrayexpress
ProteomicsRAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR
Uveal melanoma (UM) is a high fatality cancer. It arises in the eye and spreads (metastasizes) to the liver in 50% of affected patients, with a low survival rate of 5 years. In >85% of patients, their ocular tumors have mutations in specific genes, GNAQ and GNA11, leading to tumor progression and me...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD068873 | Pride
Uveal melanoma Liver metastasis. Mnk1/2 Rab1a Mtor 
ProteomicsHuman Uveal Melanome-surfaceome
A quantitative surface biotin-labeling approach combined with mass spectrometry was used to identify differentially expressed surface proteins in uveal melanoma (UM) cells, in which RAB1A was either knocked down or overexpressed, compared with the respective controls.
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069080 | Pride
Uveal melanome Surface proteome 
UnknownCross-sectional study of the prevalence of prescription opioids misuse in French patients with chronic non-cancer pain: An update with the French version of the POMI scale.
Not available
S-EPMC9484362 | biostudies-literature
TranscriptomicsTranscriptomic profiling of chicken adipose tissue in response to insulin neutralization and fasting
Domestic broiler chickens rapidly accumulate adipose tissue due to intensive genetic selection for rapid growth and are naturally hyperglycemic and insulin resistant, making them an attractive addition to the suite of rodent models used for studies of obesity and type 2 diabetes in humans. Furthermo...
ORGANISM(S): Gallus gallus 
2012-06-21 | E-GEOD-35581 | biostudies-arrayexpress
UnknownWhite blood count, D-dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID-19 patients: The French multicenter CLOTVID retrospective study.
Not available
S-EPMC8239942 | biostudies-literature
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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