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ProteomicsEvaluating protein crosslinking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monomers that seed toxic aggregates. Considerable resear...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-17 | PXD047030 | Pride
Cross-linking Pharmacological chaperone Amyotrophic lateral sclerosis (als) Stabilization Sod1 
UnknownRevisiting ABC Transporters and Their Clinical Significance in Glioblastoma.
Not available
S-EPMC11769420 | biostudies-literature
TranscriptomicsRheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from th...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat mechanically ventilated lungs from strains resistant or susceptible to ventilation-associated lung injury (VALI)
We sought to confirm the genetic influence in the development of Ventilation-Associated Lung Injury (VALI) and, in the process, identify potential candidate genes involved in the disease by integrating differential gene expression profiling on rat lungs to a traditional strain survey analysis of the...
ORGANISM(S): Rattus norvegicus 
2007-10-31 | E-GEOD-7041 | biostudies-arrayexpress
UnknownElectropermanent magnet actuation for droplet ferromicrofluidics.
Not available
S-EPMC5003119 | biostudies-literature
TranscriptomicsMycobacterium tuberculosis TraSH experiment: Growth in wild type C57BL/6J versus iNOS-/- mice
A M. tuberculosis transposon library was used to infect WT and iNOS-/- mice. Surviving mutants were recovered from spleens, genomic DNA was extracted, and labeled probes were synthesized from transposon ends. Probes from each WT mouse were hybridized with probes from a similar iNOS-/- mouse. Two-c...
ORGANISM(S): Mycobacterium tuberculosis 
2009-08-20 | E-GEOD-17706 | biostudies-arrayexpress
TranscriptomicsRheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from th...
ORGANISM(S): Homo sapiens 
2010-01-28 | GSE19821 | GEO
TranscriptomicsTranscription profiling of fission yeast as telomeres shorten in trt1- strains, and to compare survivors with linear and circular chromosomes
Time course experiment to watch RNA expression profiles as telomeres shorten in trt1- strains, and to compare survivors with linear and circular chromosomes.
ORGANISM(S): Schizosaccharomyces pombe 
2005-03-01 | E-MEXP-201 | biostudies-arrayexpress
TranscriptomicsBiomarker genes highlight intraspecific and interspecific variations in the responses of Pinus taeda L. and Pinus radiata D. Don to Sirex noctilio F. acid gland secretions
Sirex noctilio F., a Eurasian horntail woodwasp recently introduced into North America, oviposits in pines and other conifers and in the process spreads a phytopathogenic fungus that serves as a food source for its larvae. During oviposition the woodwasp also deposits a mucus produced in its acid (...
ORGANISM(S): Pinus taeda 
2012-08-09 | E-GEOD-40000 | biostudies-arrayexpress
UnknownPhase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer.
Not available
S-EPMC3577951 | biostudies-literature
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