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TranscriptomicsKnockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion
Genome-wide association studies have convincingly implicated several novel genes in susceptibility to schizophrenia and bipolar disorder. The first genome-wide significant association with the broad phenotype of psychosis was with a polymorphism in the ZNF804A gene. However, the biological function(...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28725 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of three clonal neural stem cell lines derived from human foetal spinal cord tissue.
Stem cells have received substantial interest both for their potential as in vitro tools to study development and as potential therapeutic agents in a range of degenerative diseases of the nervous system. We have generated clonal neural stem cell lines from human foetal spinal cord conditionally imm...
ORGANISM(S): Homo sapiens 
2012-06-15 | E-GEOD-37282 | biostudies-arrayexpress
TranscriptomicsTranscriptional consequences of DISC1 knockdown in human neural progenitor cells
Background: One of the strongest identified risk factors for major psychiatric illness is a chromosomal translocation directly disrupting the DISC1 gene, which is observed in members of a large Scottish family. Although DISC1 is known to function through a variety of molecular pathways, no global as...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-35548 | biostudies-arrayexpress
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