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UnknownDNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial.
BACKGROUNDRV144 is the only preventive HIV vaccine regimen demonstrating efficacy in humans. Attempting to build upon RV144 immune responses, we conducted a phase 1, multicenter, randomized, double-blind trial to assess the safety and immunogenicity of regimens substituting the DNA-HIV-PT123 (DNA) v...
S-EPMC6819112 | biostudies-literature
ProteomicsStructure of Anabaena flos-aquae gas vesicles revealed by cryo-ET
Gas Vesicles (GVs) are gas-filled protein nanostructures employed by several species of bacteria and archaea as flotation devices to enable access to optimal light and nutrients. The unique physical properties of GVs have led to their use as genetically-encodable contrast agents for ultrasound and M...
ORGANISM(S): Dolichospermum flos-aquae 04-10 
2023-03-30 | PXD038631 | Pride
Cryo-et. Gas vesicles 
UnknownBdellovibrio electron cryotomography tilt-series acquired by continuous tilting
Not available
EMPIAR-10225 | biostudies-other
UnknownBdellovibrio bacteriovorus electron cryotomography tilt-series acquired by fast-incremental method
Not available
EMPIAR-10226 | biostudies-other
UnknownCryo electron tomography of H. neapolitanus alpha-carboxysomes
Not available
EMPIAR-11125 | biostudies-other
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.

Background

Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the se...
S-EPMC7787219 | biostudies-literature
UnknownLoss of function of FAM177A1, a Golgi complex localized protein, causes a novel neurodevelopmental disorder.

Purpose

The function of FAM177A1 and its relationship to human disease is largely unknown. Recent studies have demonstrated FAM177A1 to be a critical immune-associated gene. One previous case study has linked FAM177A1 to a neurodevelopmental disorder in 4 siblings.

Methods

We identifi...
S-EPMC11451386 | biostudies-literature
UnknownGlobal, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Not available
S-EPMC4340604 | biostudies-literature
UnknownA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulator...
S-EPMC9388392 | biostudies-literature
UnknownImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.

Background

Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such...
S-EPMC9793579 | biostudies-literature
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