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Monitoring Homology Search during DNA Double-Strand Break Repair in vivo

Homologous recombination (HR) is crucial for genetic exchange, accurate repair of DNA double-strand breaks and pivotal for genome integrity. HR uses homologous sequences for repair, but how homology search, the exploration of the genome for homologous DNA sequences, is conducted in the nucleus remai...

ORGANISM(S): Saccharomyces cerevisiae

2013-03-21 | E-GEOD-44844 | biostudies-arrayexpress

The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells

Different from canonical ubiquitin-like proteins, Hub1 does not form covalent conjugates with substrates but binds proteins non-covalently. In Saccharomyces cerevisiae, Hub1 associates with spliceosomes and mediates alternative splicing of SRC1, without affecting pre-mRNA splicing generally. Human H...

ORGANISM(S): Homo sapiens

2014-05-30 | E-GEOD-56878 | biostudies-arrayexpress

The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells.

Not available

S-EPMC4141198 | biostudies-literature

Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.

Not available

S-EPMC4196982 | biostudies-literature

Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity.

Not available

S-EPMC11962092 | biostudies-literature

Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P<sub>2</sub>.