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ProteomicsPalmitoylation of BMPR1a regulates neural stem cell fate
Neural stem cells (NSCs) generate neurons and glial cells throughout embryonic and postnatal brain development. The role of s-acylation, a reversible post-translational lipid modification of proteins, in regulating fate and activity of NSCs remains largely unknown. We here used an unbiased screening...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-27 | PXD014355 | Pride
Abe Nsc 
ProteomicsA fatty acid oxidation-dependent metabolic shift regulates adult neural stem cell quiescence
Adult hippocampal neurogenesis is important for certain forms of cognition and failing neurogenesis has been implicated in neuropsychiatric diseases. The neurogenic capacity of hippocampal neural stem/progenitor cells (NSPCs) depends on a balance between quiescent and proliferative states. However, ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-15 | PXD005598 | Pride
Quiescence Fatty acid oxidation Neural stem cell 
ProteomicsFASN-dependent de novo lipogenesis is required for brain development
Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. H...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD026110 | Pride
Fasn Human Mouse Lipogenesis Brain development Brain organoids 
TranscriptomicsA mechanism for the segregation of age in mammalian neural stem cells
Across life neural stem cells (NSCs) generate new neurons in the mammalian brain through asymmetric neurogenic and self-renewing cell divisions. However, the cellular mechanisms underlying NSC asymmetry remain unknown. Using fluorescence loss in photobleaching (FLIP) we here show that NSCs in vitro ...
ORGANISM(S): Mus musculus 
2015-09-22 | E-GEOD-61367 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis
Neural stem cells (NSCs) generate new neurons throughout life in two distinct areas of the mammalian brain: the subventricular zone (SVZ) lining the lateral ventricles and the hippocampal dentate gyrus (DG). How gene expression signatures differ among NSCs and immature neurons within and between the...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-21208 | biostudies-arrayexpress
TranscriptomicsMetabolic control of adult neural stem cell activity by FASN-­dependent lipogenesis
Mechanisms controlling the proliferative activity of neural stem/progenitor cells (NSPCs) play a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (FASN), the key enzyme o...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-27391 | biostudies-arrayexpress
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